introduction: up to 12% of patients undergoing coronary artery bypass graft have pulmonary complications. smoking can cause a six-time increase in pulmonary complication after major surgery. the most common pulmonary changes after cabg are decrease in frc, vc and atelectasis. in this study, the effect of oral n-acetyl-cystein in reduction of severity of hypoxemia and atelectasis in current smok...

Background: This study was undertaken to investigate whether treatment with vitamin E and N acetyl cystein protects rat sperm by inhibiting reactive oxygen species generation induced by lead (Pb) exposure. Materials and Methods: After an acclimatization period of one week, 20 Male rats were divided into 4 groups of 5 rats each. Animals within different treatment groups were maintained on their ...

Background and Aims: Formaldehyde, a colorless aldehyde with pungent odor, has negative effects on systems of the body. Considering, there are a little data about protective substances against kidney damage induced by formaldehyde, the aim of the present study was to examine the effects of different doses of N-acetyl cysteine on biochemical and histopathological parameters in k...

The synthesis of N-acetyl derivatives of α-amino acids (L–Gly, L–Val, L–Phe, L–Ile, L–Pro and L–Cys) using a simple and efficient method for preparation was carried out. The N-acetyl derivatives were obtained using acetic anhydride in basic conditions at room temperature. The methyl amides of N–acetyl amino acid were synthesized by mixed anhydride procedure using a Piv–Cl as a reagent. The conv...

The structures of six inhibitors of prolyl hydroxylase, fibrostatins A, B, C, D, E and F produced by a strain of Streptomyces, were deduced to be 1, 2, 3, 4, 5 and 6, respectively, from chemical and spectroscopic evidence, especially from extensive 13C NMR studies including selective decoupling and low power selective decoupling experiments monitored by 13C-1H long-range couplings. These compou...

Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA...

BACKGROUND Increased levels of reactive oxygen species during and after surgery may affect inflammatory response, post-operative adhesion molecule formation, and hemodynamic stability. The glutathione redox cycle is an important regulator in oxidative stress and its reduced forms scavenge free radicals. N-acetyl cysteine, a precursor of reduced glutathione, is considered as a potentially therap...

introduction: 3-4, methylenedioxymethamphetamine (mdma) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to mdma-induced neurotoxicity. the aim of this study is to examine the effects of n-acetyl-l-cystein (nac) as an antioxidant on mdma-induced apoptosis. methods: 21 sprague dawley male rats (200-250mg) were treated with mdma (2×0,5mg/kg) or mdma...