نتایج جستجو برای: N7

تعداد نتایج: 848  

Journal: :Chemical and Pharmaceutical Bulletin 1982

Journal: :Zeitschrift fur Naturforschung. Section C, Biosciences 1984
R Oliński Z Walter

The method presented here enables the isolation of three monofunctional adducts. These are: platination of cytosine, adenine and guanosine. The three detected bifunctional complexes were: guanine N7 to N7, adenine N7 to N7 and adenine N7 to N1. A mixed bifunctional complex of guanine and adenosine and the product of polymerization of three adenines and two moieties of cis DDP were also detected...

2011
Surajit Banerjee Kyle L. Brown Martin Egli Michael P. Stone

Aflatoxin B(1) (AFB(1)) is oxidized to an epoxide in vivo, which forms an N7-dG DNA adduct (AFB(1)-N7-dG). The AFB(1)-N7-dG can rearrange to a formamidopyrimidine (AFB(1)-FAPY) derivative. Both AFB(1)-N7-dG and the β-anomer of the AFB(1)-FAPY adduct yield G→T transversions in Escherichia coli, but the latter is more mutagenic. We show that the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4)...

Journal: :Metal-Based Drugs 1997
Margarita Vicens Amparo Caubet Virtudes Moreno

The interaction of the dinucleotides d(ApG) and d(ApA) with [Pd(aa)Cl(2)], where aa = L- or D-histidine or the methyl ester of L-histidine, and with [Pt(Met)Cl(2)], where Met = L-methionine was studied by (1)H and (13)C NMR and CD measurements. In the case of the L-histidine and L-histidineOMe, the reaction with d(ApG) appeared to give the bifunctional adducts Pd(L-Histidine)N1(1)N7(2) and Pd(L...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Yu Chen Hui Cai Ji'an Pan Nian Xiang Po Tien Tero Ahola Deyin Guo

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In this report, we used a yeast genetic system to functionally screen for the cap-forming enzymes encoded by severe acute respiratory syndrome (SARS) coronavirus and identified the no...

Journal: :Chemistry 2011
Larisa E Kapinos Bert P Operschall Erik Larsen Helmut Sigel

Adenosine (Ado) can accept three protons, at N1, N3, and N7, to give H(3) (Ado)(3+) , and thus has three macro acidity constants. Unfortunately, these constants do not reflect the real basicity of the N sites due to internal repulsions, for example, between (N1)H(+) and (N7)H(+). However, these macroconstants are still needed for the evaluations and the first two are taken from our own earlier ...

Journal: :Sustainability 2022

Heat stress has a strong and detrimental effect on plant growth yield. Goji berry or wolfberry (Lycium barbarum L.) is dual-purpose medicinal food but an increase in high temperatures caused serious decline yield quality. In this study, we first explored the heat responses of berry, found that adaptation mechanisms fluctuated over 48 h. Moreover, L.barbarum 1402 was more resistant while Ningqi ...

Journal: :Nucleic acids research 1993
Y G Gao M Sriram A H Wang

Metal ion coordination to nucleic acids is not only required for charge neutralization, it is also essential for the biological function of nucleic acids. The structural impact of different metal ion coordinations of DNA helices is an open question. We carried out X-ray diffraction analyses of the interactions of the two transition metal ions Co(II) and Cu(II) and an alkaline earth metal ion Ba...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006
Abir A Saad Peter J O'Connor Mostafa H Mostafa Nabila E Metwalli Donald P Cooper Geoffrey P Margison Andrew C Povey

Schistosoma haematobium-infected patients are more likely to develop bladder cancer and be more exposed to carcinogenic N-nitroso compounds than uninfected patients. As N7-methylguanine is a marker of exposure to methylating agents of this type, we have measured N7-methyldeoxyguanosine 3'-monophosphate (N7-MedGp) by (32)P postlabeling. DNA was isolated from 42 paired normal and tumor tissue of ...

Journal: :Neuro-oncology 2007
William J Bodell Alexander P Bodell Donald D Giannini

The alkylation products formed by in vitro treatment of DNA with tritium-labeled 1,3-bis(2-chloroethyl)-1-nitrosourea ((3)H-BCNU) were identified and quantified. Twelve adducts were resolved by high-performance liquid chromatography (HPLC). The principal DNA adducts formed by BCNU treatment corresponded to N-7-(2-hydroxyethyl)guanine (N7-HOEtG) (26%), N-7-(2-chloroethyl)guanine (15%), and phosp...

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