The following MOEA algorithms are briefly summarized and compared: • NPGA Niched Pareto Genetic Algorithm (1994) – NPGA II (2001) • NSGA Non-dominated Sorting Genetic Algorithm (1994) – NSGA II (2000) • SPEA Strength Pareto Evolutionary Algorithm (1998) – SPEA2 (2001) – SPEA2+ (2004) – ISPEA Immunity SPEA (2003) • PAES Pareto Archived Evolution Strategy (2000) – M-PAES Mimetic PAES (2000) • PES...

A kind of unrelated parallel machines scheduling problem is discussed. The memberships of fuzzy due dates denote the grades of satisfaction with respect to completion times with jobs. Objectives of scheduling are to maximize the minimum grade of satisfaction while makespan is minimized in the meantime. Two kind of genetic algorithms are employed to search optimal solution set of the problem. Bo...

OBJECTIVES Masking ability of a restorative material plays a role in hiding colored substructures; however, the masking ability of zirconia ceramic (ZRC) has not yet been clearly understood in zirconia-based restorations. This study evaluated the effect of three different core materials on masking ability of a ZRC. MATERIALS AND METHODS Ten zirconia disc samples, 0.5mm in thickness and 10mm i...

We present a multi-objective genetic algorithm for mining highly predictive and comprehensible classification rules from large databases. We emphasize predictive accuracy and comprehensibility of the rules. However, accuracy and comprehensibility of the rules often conflict with each other. This makes it an optimization problem that is very difficult to solve efficiently. We have proposed a mul...

Two fungal cyclooligomer depsipeptide synthetases(CODSs), BbBEAS (352 kDa) and BbBSLS (348 kDa) from Beauveria bassiana ATCC7159, were reconstituted in Saccharomyces cerevisiae BJ5464-NpgA, leading to the production of the corresponding anticancer natural products, beauvericins and bassianolide, respectively. The titers of beauvericins (33.8 ± 1.4 mg/l) and bassianolide (21.7± 0.1 mg/l) in the ...

BACKGROUND Polyketides are one of the most important classes of secondary metabolites and usually make good drugs. Currently, heterologous production of fungal polyketides for developing a high potential industrial application system with high production capacity and pharmaceutical feasibility was still at its infancy. Pichia pastoris is a highly successful system for the high production of a v...

Design of any complex system entails many objectives to reach and constraints to satisfy. This multi–objective nature of the problem ensures that the technology solution is always a compromise between conflicting objectives. The purpose of this paper is to demonstrate the application of Niched Pareto genetic algorithm as a relatively fast and straightforward method for obtaining technology sets...

Polyketide synthases (PKSs) and/or nonribosomal peptide synthetases (NRPSs) are central components of secondary metabolism in bacteria, plants, and fungi. In filamentous fungi, diverse PKSs and NRPSs participate in the biosynthesis of secondary metabolites such as pigments, antibiotics, siderophores, and mycotoxins. However, many secondary metabolites as well as the enzymes involved in their pr...

objectives: masking ability of a restorative material plays a role in hiding colored substructures; however, the masking ability of zirconia ceramic (zrc) has not yet been clearly understood in zirconia-based restorations. this study evaluated the effect of three different core materials on masking ability of a zrc. materials and methods: ten zirconia disc samples, 0.5mm in thickness and 10mm i...

We present a Niched Pareto Genetic Algorithm (NPGA) approach to the scheduling of scientific workflows in a wireless grid environment that connects computational resources, wired grids and wireless device resources such as cameras, microphones, network interfaces and so forth where the maximization of job completion ratio and minimization of lateness is crucial. Our approach supports handling u...