among the drug delivery and targeting (ddt) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. however, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. thus, in the current study, impact of dexamethason...

Investment in nanotechnology is now a given constant by governments, research centers and companies in both more developed countries and emerging markets. Due to their characteristics, such as high stability, ability to enable antigen identification on specific cells in the human body and controlling the release of drugs and, therefore, improving therapies, nanoparticles have been the subject o...

Department of Nanopharmaceutical Scienc Nagoya Institute of Technology, Gokiso, Sho [email protected]; Fax: +81-52-735-754 Department of Life Science and Medical Wakamatsu-cho 2-2, Shinjuku-ku, Tokyo 16 Consolidated Research Institute for Advan University (ASMeW), Waseda-tsurumaki-cho † Electronic supplementary information ( 1009506, 1009507, 1009508, 1009509. For other electronic format se...

Macromolecular biomolecules are currently dethroning classical small molecule therapeutics because of their improved targeting and delivery properties. Protamine-a polycationic peptide-represents a promising candidate. In nature, it binds protects DNA against degradation during spermatogenesis due to electrostatic interactions between the negatively charged DNA-phosphate backbone positively pro...

1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. 2Genome Research Center for Diabetes and Endocrine Disease, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. 3Age-Related and Brain Diseases Research Center, Department of Nanopharmaceutical and Life Sciences, Kyung Hee University, Seoul, Korea. 4Department of Clinical La...

CRLX101 is a cyclodextrin-based nanopharmaceutical designed to improve the delivery and efficacy of anti-cancer drug camptothecin. Cyclodextrins have unique properties that can enhance solubility, stability, bioavailability, making them an attractive option for delivery. The use nanoparticles potentially reduce toxicity increase therapeutic index compared conventional chemotherapy. has shown pr...

Nanobiotechnology, involving biological systems manufactured at the molecular level, is a multidisciplinary field that has fostered the development of nanoscaled pharmaceutical delivery devices. Micelles, liposomes, solid lipid nanoparticles, polymeric nanoparticles, functionalized nanoparticles, nanocrystals, cyclodextrins, dendrimers, nanotubes and metallic nanoparticles have been used as str...

Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...