نتایج جستجو برای: Napsin-A

تعداد نتایج: 13431798  

Journal: :International journal of clinical and experimental pathology 2015
Qing Li Xin Zeng Xue Cheng Jingmin Zhang Jie Ji Jinsong Wang Kemei Xiong Qiong Qi Wenbin Huang

We evaluated the diagnostic value of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma. Immunohistochemical EnVision was used to measure HNF-1β and napsin A expression in 38 cases of ovarian clear cell carcinoma, 30 cases of high-grade serous carcinoma, 22 cases of endometrioid adenocarcinoma, and 16 metastatic Krukenberg tumor cases. Then we fou...

2012
Takuya Samukawa Tsutomu Hamada Hirofumi Uto Masakazu Yanagi Go Tsukuya Tsuyoshi Nosaki Masahiro Maeda Takashi Hirano Hirohito Tsubouchi Hiromasa Inoue

BACKGROUND Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determine whether napsin A could be measured in the serum to evaluate its relationship to idiopathic pulmonary fibrosis (IPF) and determine whether renal dysfunction might affect serum...

2015
Bing Zhu Stephen M Rohan Xiaoqi Lin

BACKGROUND Immunohistochemistry (IHC) for napsin A has been widely used to support a diagnosis of lung adenocarcinoma with high sensitivity. In this study, we evaluated immunoreactivity for napsin A in a broad spectrum of renal neoplasms by using tissue microarrays (TMA). METHODS Duplicate TMA of 159 surgically excised renal neoplasms of various types were constructed. IHC for napsin A was pe...

2017
Akifumi Uchida Takuya Samukawa Tomohiro Kumamoto Masahiro Ohshige Kazuhito Hatanaka Yoshihiro Nakamura Keiko Mizuno Ikkou Higashimoto Masami Sato Hiromasa Inoue

BACKGROUND It is crucial to develop novel diagnostic approaches for determining if peripheral lung nodules are malignant, as such nodules are frequently detected due to the increased use of chest computed tomography scans. To this end, we evaluated levels of napsin A in epithelial lining fluid (ELF), since napsin A has been reported to be an immunohistochemical biomarker for histological diagno...

Journal: :The Journal of biological chemistry 2004
Takayuki Ueno Stig Linder Cheng-Lun Na Ward R Rice Jan Johansson Timothy E Weaver

Surfactant protein B (SP-B) is an essential constituent of pulmonary surfactant. SP-B is synthesized in alveolar type II cells as a preproprotein and processed to the mature peptide by the cleavage of NH2- and COOH-terminal peptides. An aspartyl protease has been suggested to cleave the NH2-terminal propeptide resulting in a 25-kDa intermediate. Napsin, an aspartyl protease expressed in alveola...

Journal: :Diagnostic cytopathology 2012
Michael H Roh Lindsay Schmidt Jeremiah Placido Sara Farmen Kristina L Fields Anthony J Courey Douglas A Arenberg Stewart M Knoepp

The importance of subclassifying pulmonary nonsmall cell carcinoma (NSCLC) in cytologic material is becoming increasingly paramount. Occasionally, cell blocks traditionally used for ancillary studies are sparsely cellular or acellular. Hence, we investigated the diagnostic utility of immunocytochemistry for Napsin-A, TTF-1, and p63 on direct smears of NSCLC. Immunohistochemistry for Napsin-A wa...

2017
Tomokazu Ito Kozo Nakanishi Hidenori Goto

BACKGROUND We report a case of napsin A-positive metastatic lung cancer originating from the colon. No cases of napsin A-positive metastatic lung tumors originating from colorectal cancer have been reported previously. CASE PRESENTATION Computed tomography identified a small lung nodule in a 70-year-old male patient, 18 months after resection for rectal cancer. The size of the lung tumor incr...

2012
Wan Seop Kim

Purpose: Given the emerging evidence for differential responses to new targeted therapies and the identification of molecular differences between specific subtypes of non-small cell lung carcinoma (NSCLC), there is an increased need for greater accuracy in subtyping NSCLC. In a substantial proportion of cases, standard morphology cannot specifically subtype the tumor, resulting in a final diagn...

2015
Grzegorz T Gurda Lei Zhang Yuting Wang Li Chen Susan Geddes William C Cho Frederic Askin Edward Gabrielson Qing Kay Li

BACKGROUND Fine needle aspiration (FNA) biopsy plays a critical role in the diagnosis and staging of lung primary and metastatic lung carcinoma. Accurate subclassification of adenocarcinoma (ADC) and/or squamous cell carcinoma (SqCC) is crucial for the targeted therapy. However, the distinction between ADC and SqCC may be difficult in small FNA specimens. Here, we have retrospectively evaluated...

2017
Marina Piljić Burazer Suzana Mladinov Vesna Ćapkun Sendi Kuret Merica Glavina Durdov

BACKGROUND The present study was carried out in order to evaluate our institutional experience with small biopsy in diagnosis and molecular testing of lung adenocarcinoma. Few specific and predictive markers have been evaluated and correlated with clinicopathologic characteristics and survival in patients with lung adenocarcinoma who received platinum-based chemotherapy. There have not been suc...

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