central nervous system axons fail to regenerate after spinal cord injury (sci), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. this study evaluated the histological changes (cavitation and axon regeneration) after sci associated with (following ad...

introduction: ischemic stroke is amongst the top four causes of mortality and the leading cause of disability in the world. the aim of this study was to evaluate the efficacy of a high dose memantine on neurological function of patients with ischemic stroke.methods: in a randomized, 2 armed, open-label study, patients with mild to moderate cerebral thromboembolic event (ctee) who admitted to im...

coenzyme q10 is a promising   agent for neuroprotection in neurodegenerative   diseases. neuroprotective effects of coenzyme q10 demonstrated in some   neurodegenerative diseases such as parkinson, alzheimer and etc. hippocampus   is home of these diseases. we assayed coenzyme q10 effects on hippocampal   injury model and our hypothesis is that coenzyme q10 has neuroprotective   effects in some...

apoptosis plays an important role in many pathological processes of the central nervous system. the neuroprotective effect of periodic fasting (pf) in contrast to severe fasting or starvation has been suggested. however, these beneficial effects seem to depend on the type and duration of the used feeding protocol. this study was designed to evaluate the effects of different pf protocols on the ...

introduction: multiple sclerosis (ms) has been recognized as a common neurodegenerative disease that occurs after an auto reactive t cells against myelin antigens.  demyelination and inflammation are the main features of this disease. the anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (bm-mscs) have been considered as a suitable treatment against autoi...

objective(s): some histopathological alterations take place in the ischemic regions following brain ischemia. recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral...

Objective(s): Stroke may cause severe neuronal damage. The sesamin have been demonstrated to possess neuroprotection by its antioxidant and anti-inflammatory properties. One sesamin derivative was artificially composited, 1, 2-bis [(3-methoxyphenyl) methyl] ethane-1, 2-dicaroxylic acid (MMEDA) had been developed to study its antioxidative activity and neuroprotection. Materials and Methods: The...

results brdu ihc showed a significant decrease in neurogenesis following tld in both sexes showing more severity in male rats than in female rats. results of nissl staining and mwm also confirmed the brdu findings. regarding sexual dimorphism, our data showed no significant sex differences in the dg area of the hippocampus. conclusions sex-dependent reduction in neurogenesis following tld could...

neuroprotective effect of the extract from aerial parts of scrophularia striata boiss(scrophulariaceae) was investigated against glutamate-induced neurotoxicity on cultured rat pupscerebellar granule neurons (cgns). cgns from 8 days old sprague-dawley rat were preparedand cultured. the experiments were performed after 8 days in culture. the plant was collected fromthe northeastern part (ruin re...