alcohol provokes different molecular pathways contributing to a clinically significant neurotoxicity in different brain areas. affected cognition in alcoholics can influence both daily life functioning and alcohol craving management abilities. preventing alcohol-induced neurotoxicity with different neuroprotective pharmacological interventions is receiving strong scientific backgrounds from pub...

background: acrylamide (acr) is a well-known industrial toxic chemical that produces neurotoxicity, which is characterized by progressive central and peripheral neuronal degeneration. chrysin is a natural, biologically active flavonoid compound, which is commonly found in many plants. the antioxidant and neuroprotective properties of chrysin have been demonstrated. methods: in this study, the p...

objective: hexavalent chromium [cr (vi)] compounds are well-known environmental contaminants  generated from industrial processes. several studies have reported the harmful effects of cr (vi) on different organs, however, little is known about neurotoxic effects of cr (vi). the aim of this study is to investigate the toxic effects of cr (vi) on pc12 cells. methods: pc12 cells were cultured foll...

objective(s):silver nanoparticles (ag-nps) are used widely in bedding, water purification, tooth paste and toys. these nanoparticles can enter into the body and move into the hippocampus. the aim of this study was to investigate the neurotoxicity of silver nanoparticles in the adult rat hippocampus. materials and methods:12 male wistar rats were randomly divided into two experimental and contro...

conclusions as green tea is an essential source of antioxidants such as flavonoids, suppression of reactive oxygen species (ros) generation may be in part considered as the neuroprotective mechanism on acr induced neurotoxicity. background acrylamide (acr) monomer is an effective neurotoxicant, which damages the central and peripheral nervous systems in humans and animals. green tea, an infusio...

objective concern for side-effects of therapy related to treatment of childhood malignancies is becoming an increasingly important topic. in this study, we evaluated extent of vincristine (vcr) induced neurotoxicity in a group of children who underwent chemotherapy, with vcr being part of the regimen. materials & methods in this investigation, for 75 children (54% boys, 46% girls), aged between...

background and objectives: there is well established the beneficial effects of crocus sativus extract in learning and memory improvement. in the present study the effect of this plant in memory behavioral impairment and forbrain histological damage induced by stz-icv model of alzheimer disease were investigated. materials and methods: this study was conducted at shahed university (tehran) in 20...

a series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4h-1,2,4-triazole was synthesized. the anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (mes) test and rotarod tests with intraperitoneally injected mice. among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4h-1,2,4-triazole (5f) was the most active one and also had...

background: the use of organophosphates (ops) in developing countries is rising in large quantities and non-secure methods. this problem not only causes acute poisoning but also may lead to chronic diseases such as polyneuropathy. in iran, 60% of pesticides are organophosphate compounds that may lead to delayed polyneuropathy. objectives: the purpose of the current study was to evaluate delayed...