nezam-abad area is located in southwest of shazand (arak) which is a part of sanandaj-sirjan zone. major intrusive rocks of nezam-abad are quartz diorite and minor amount of granodiorite. leucogranitic, pegmatite dykes and quartz-tourmaline veins were intruded the quartz diorite. quartz diorites are mainly composed of plagioclase, hornblende, biotite, quartz and pyroxene as major minerals. majo...

tourmalinization characterizes the most pervasive alteration type in the nezam abad ore deposit, west-central iran. it delineates high-temperature centers of mineralization and together with quartz and cassiterite form inner parts of the alteration halo. the composition of tourmalines plots mostly along and between the proton and alkali-deficient end members. tourmaline in quartzdioritic host i...

Sediments of the Nezam-Abad area, south-east of Bam have been studied for the first time. Sedimentary facies are composed of thin-bedded clay, silt and fine grained sand interbedded with thin laminated limestone. Chemical analysis of X-Ray florescent indicates that more than 50% of sediments consist of silisium and aluminum oxide that can be used for reconstruction of environment. Ninety eight ...

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial de...

Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-A...

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we report the biological activity of small molecule ABAD inhibitors. Using in vitro su...

sediments of the nezam-abad area, south-east of bam have been studied for the first time. sedimentary facies are composed of thin-bedded clay, silt and fine grained sand interbedded with thin laminated limestone. chemical analysis of x-ray florescent indicates that more than 50% of sediments consist of silisium and aluminum oxide that can be used for reconstruction of environment. ninety eight ...

Patients with acute type B aortic dissection (ABAD) are often treated medically. However, ABAD is a potentially serious emergency if complicated by acute organ ischemia. The therapeutic strategy for ABAD with visceral malperfusion remains controversial. Because emergent surgery has a high mortality rate, emergent endovascular treatment can be performed instead. We report a case of endovascular ...

Patients with uncomplicated acute type B aortic dissection (ABAD) can generally be treated with conservative medical management. However, these patients may develop aortic enlargement during follow-up, with the risk of rupture. Several predictors have been studied in recent years to identify ABAD patients at high risk of aortic enlargement, who may benefit from early surgical or endovascular in...