objective: menopause is the condition when regular menstrual periods cease and may be accompanied by psychological and physical symptoms. the purpose of current study was to determine nigella sativa effects on reproductive system in experimental menopause animal models. materials and methods: a series of experiments wasconducted to investigate the effects of different dosages of n. sativa (firs...

In the previous studies the relaxant, anti-cholinergic (functional antagonism) and anti-histaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the main substance responsible for the relaxant effect of this plant, the effect of thymoquinone, one of the main constituent of Nigella sativa was examined in this study. The bronchodilatory effects of th...

The loss of the ability for learning and memory is a prominent feature of dementia, which affects millions of individuals all over the world, due to either neurodegenerative diseases or brain injury. Although a lot of information is known about the pathology involved, treatment remains elusive at best. The Black Seed of Nigella sativa has been historically and religiously used for thousands of ...

Effects of magnetic hydroethanolic extract Nigella sativa and magnesium oxide nanoparticles (MgO) on catalase gene expression in liver diabetic male rats

Background and Aim: Nigella sativa with anti-inflammatory and antimicrobial effects is one of the most widely used medicinal plants that can be used as an alternative or adjunctive therapy due to many side effects of chemical drugs. The aim of this study was to evaluate the regenerative and protective effects of Nigella sativa from pathological point of view in rat gastrointestinal tract. Mate...

background: nigella sativa (n. sativa) seeds are used to treat diabetes mellitus in traditional medicine. moreover, n. sativa oil has reduced the fasting blood glucose level in non-diabetic volunteers. objective: the present study was undertaken to explore the possible anti-hyperglycemic effect of n. sativa oil in type ii diabetic patients. methods: a randomized clinical trial was conducted in ...

objectives: dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. in the present study, the effects of thymoquinone, the major constituent of nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. materials and methods: male adult nmri mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 7...

objective: inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. materia...

BACKGROUND Natural products are proved to play a good role as an alternative to synthetic chemicals in many clinical conditions. Hypercholesterolemia is the most important risk factor for atherosclerosis. Previous studies showed that Nigella sativa L. has both antioxidant and lipid lowering potentials. THE AIM OF THIS STUDY To evaluate the efficacy of the seeds of Nigella sativa on the treatm...