BACKGROUND Here, phytochemical profile of Nitraria retusa (N. Retusa) leaf extracts was identified and their ability to induce apoptosis and inhibiting growth of melanoma cells and enhancing melanogenesis of B16F10 melanoma was evaluated. METHODS The Apoptosis was evidenced by investigating DNA fragmentation, and Acridine orange/ethidium bromide staining. Amounts of melanin and tyrosinase wer...

Title: Isorhamnetin 3-O-robinobioside from Nitraria retusa leaves enhance antioxidant and antigenotoxic activity in human chronic myelogenous leukemia cell line K562

The present work was undertaken to evaluate the polyphenolic content, antioxidant and antiviral properties of two wild medicinal plants; Achillea fragrantissima and Nitraria retusa. The crude extracts of both plants were prepared using methanol and ethyl acetate solvents. Generally, total phenolic content ranged from 0.31 to 15.05 mg gallic acid equivalents /g dw, where total flavonoid content ...

BACKGROUND In this report, the isorhamnetin 3-o-robinobioside and its original extract, the ethyl acetate extract, from Nitraria retusa leaves, were evaluated for their ability to induce antioxidant and antigenotoxic effects in human chronic myelogenous leukemia cell line. METHODS Nitraria retusa products properties were carried out by firstly evaluating their effects against lipid peroxidati...

Nitraria retusa is an edible halophyte, used in Tunisia for several traditional medicine purposes. The present study investigated the antiobesity effects of Nitraria retusa ethanol extract (NRE) in 3T3-L1 cells using different doses and in high-fat diet-induced obesity in mice. Male C57B6J/L mice were separately fed a normal diet (ND) or a high-fat diet (HFD) and daily administrated with NRE (5...

Six wild populations of Nitraria retusa growing in Tunisia (Mehdia, Mtorech, Kataena, Matmata, Bechima, and Tataouine) were evaluated for their mineral contents, phytochemical composition, phenols content and antioxidants activity. The preliminary composition revealed the presence of phenolic compounds such as flavonoids, sterols terpenes free quinones. Analysis showed pover...