JNK proteins are ubiquitously expressed, evolutionarily conserved MAP kinases that are involved in stress responses. Recently, it was shown that the JNK cascade in Xenopus oocytes exhibits sustained, all-or-none responses to graded, transient stimuli. Here, we have examined the character of the JNK cascade's response in mammalian cells. The steady-state responses of JNK to sorbitol and anisomyc...

Copyright: © 2011 Magdeldin S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Sporadic congenital none-autoimmune hyperthyroidism is rare disease. It causes the gain of function with TSH receptor gene mutation. We report 3 months old Japanese boy with sporadic congenital none-autoimmune hyperthyroidism. Our case was born in the 34th week of gestation with a birth weight 1830g, his length 42.0cm, his head circumference 29.5 cm as low birth weight baby between non consangu...

Models of consciousness differ in whether they predict a gradual change or a discontinuous transition between nonconscious and conscious perception. Sergent and Dehaene (Psychological Science, 15, 720-728, 2004) asked subjects to rate on a continuous scale the subjective visibility of target words presented during an attentional blink. They found that these words were either detected as well as...

The sense of hearing achieves its striking sensitivity, frequency selectivity, and dynamic range through an active process mediated by the inner ear's mechanoreceptive hair cells. Although the active process renders hearing highly nonlinear and produces a wealth of complex behaviors, these various characteristics may be understood as consequences of a simple phenomenon: the Hopf bifurcation. An...

Xenopus oocytes convert a continuously variable stimulus, the concentration of the maturation-inducing hormone progesterone, into an all-or-none biological response-oocyte maturation. Here evidence is presented that the all-or-none character of the response is generated by the mitogen-activated protein kinase (MAPK) cascade. Analysis of individual oocytes showed that the response of MAPK to pro...

In spite of the hype in the international media about India’s global integration, economic reform there has been rather halting and hesitant. Cheerleaders of reform among corporate tycoons and financial columnists are often not aware how unpopular reform is, rightly or wrongly, among the general public in India. In the National Election Survey 2004 more than twothirds of about 23000 sample resp...

Every time we encounter a new object, action, or event, there is some chance that we will need to assign it to a novel category. We describe and evaluate a class of probabilistic models that detect when an object belongs to a category that has not previously been encountered. The models incorporate a prior distribution that is influenced by the distribution of previous objects among categories,...

Accurate wireless indoor positioning in non line-of-sight (NLoS) environments is an open research topic due to interfering dense multipath propagation. The key challenge is to reliably detect the direct path (DP) from the transmitter to the receiver so as to enable accurate positioning calculations. In our contribution a novel approach called ”BeamLoc” has been introduced to perform this task. ...