Nosrat-Abad ophiolitic extrusive sequence, located in the Sistan Suture Zone, in south eastern Iran. The extrusive sequence, contains pillow lava, sheet flow and related volcanic-clastic breccias which have undergone low-grade metamorphism. This association shows calc alkaline to tholeiitic affinities. Interpretation of the geochemical data and behavior of the elements in different diagrams rev...

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial de...

Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-A...

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we report the biological activity of small molecule ABAD inhibitors. Using in vitro su...

Patients with acute type B aortic dissection (ABAD) are often treated medically. However, ABAD is a potentially serious emergency if complicated by acute organ ischemia. The therapeutic strategy for ABAD with visceral malperfusion remains controversial. Because emergent surgery has a high mortality rate, emergent endovascular treatment can be performed instead. We report a case of endovascular ...

Patients with uncomplicated acute type B aortic dissection (ABAD) can generally be treated with conservative medical management. However, these patients may develop aortic enlargement during follow-up, with the risk of rupture. Several predictors have been studied in recent years to identify ABAD patients at high risk of aortic enlargement, who may benefit from early surgical or endovascular in...

Sir, Acute type B aortic dissection (ABAD) is a life-threatening vascular emergency with an incidence estimated at 5-30 per 1 million people per year.[1] Available evidence support endovascular and surgical treatment for ABAD complicated by shock or organ damage. In uncomplicated ABAD, benefits of endovascular treatment are not well established and the preferred management mandates close clinic...

Alzheimer's disease (AD) is a conformational disease that is characterized by amyloid-β (Aβ) deposition in the brain. Aβ exerts its toxicity in part by receptor-mediated interactions that cause down-stream protein misfolding and aggregation, as well as mitochondrial dysfunction. Recent reports indicate that Aβ may also interact directly with intracellular proteins such as the mitochondrial enzy...

Using a new dataset, this paper presents new evidence on inequality in Latin America for the 19th century and studies the effects of factor endowments and trade on inequality. Recent research has highlighted the link between the colonial origins of inequality and its persistence in Latin America. We find that inequality varied substantially throughout the century a...

Mathews Journal of Case Reports Hydranencephaly Mohammad Nawaz Nasery1, Farhad Farzam1, Hidayatullah Hamidi2, Jamshid Sadiqi2, Ahmad Reshad Faizi2, Fazel Rahman Faizi2, Marzia Mohammadi2 1Radiology department, Ali Abad Teaching Hospital, Kabul, Afghanistan. 2Radiology department, French Medical Institute for Children (FMIC), Kabul, Afghanistan. Corresponding Author: Mohammad Nawaz Nasery, Ali A...