Background and objective: Clear Cell Renal Cell Carcinoma (CCRCC) is the most common adult renal neoplasm. Staging and grading of RCC are important predictors of survival. Fuhrman nuclear grading is widely used for CCRCC, the subjective nature of which has prompted more objective methods to evaluate nuclear features. Furthermore, Ki-67, a reliable marker of cellular pr...

background : breast carcinoma is the most common malignant tumor and leading cause of cancer deaths in women. while fine needle aspiration cytology is highly accurate in the diagnosis of breast lesions, it possesses certain drawbacks. in those circumstances intraoperative imprint cytology assumes importance, however, imprint cytology is subjected to interpretative errors. computer image analysi...

The intraobserver and interobserver reproducibility of computerized nuclear morphometry was determined in repeated measurements of 212 samples of invasive breast cancer. The influence of biological variation and the selection of the measurement area was also tested. Morphometrically determined mean nuclear profile area (Pearson's r 0.89, grading efficiency (GE) 0.95) and standard deviation (SD)...

Fifty-two spontaneous canine mammary gland tumours (fibroadenomas, n = 8, tubulopapillary carcinomas, n = 9, solid carcinomas, n = 6, anaplastic carcinomas, n = 7, fibrosarcomas, n = 9, liposarcomas, n = 9 and osteosarcomas, n = 4 were analysed by computer-assisted nuclear morphometry on Hemacolor-stained cytologic specimens. One hundred nuclei per lesion were examined. Computerized cytomorphom...