significance as calcium-channel modulators in the treatment of cardiovascular diseases, such as hypertension, cardiac arrythmias or angina.1 In recent years, interest has also been focused on aza-analogs of dihydropyridines, such as dihydropyrimidines, which show a very similar pharmacological profile to that of dihydropyridine calcium channel modulators.2 In a continuation of these studies, ri...

Sulfonated-silica-coated cobalt ferrite (CoFe2O4) magnetic nanoparticles (MNPs-SiCoFe-SO3H) are efficient heterogeneous catalysts for the synthesis of 3,4-dihydropyrimidin-2(1H)-one and octahydroquinazoline derivatives in absence solvent. The effects solvent, temperature, catalyst amount on reaction investigated. easy separation, reusability catalyst, simplicity procedure, mild conditions, good...

hydroquinazoline-2,5-dione was obtained from Biginelli-type cyclocondensation1 of 5,5-dimethylcyclohexane-1,3-dione with urea and 4-bromobenzaldehyde: yield 1.16 g (62.19%), m.p. 174 – 175 ̊C. A summary of the key crystallographic information is given in Table 1. The atomic coordinates and equivalent isotropic displacement parameters with estimated standard deviations for atoms except H are list...

In this work, preparation and crystallization of yttrium iron garnet Y3Fe5O12 super-paramagnetic nanoparticle by aqueous sol–gel processes and its application as an effective nano catalyst for esterification and etherification reactions in short reaction time and in high isolated yields. Then this catalist was used for the synthesis of Dihydropyrimidin derivatives is described. The catalyst was...