نتایج جستجو برای: Off-targeting

تعداد نتایج: 331126  

In this paper I develop a Proxy Means Tests (PMT) model and examine several targeting lines based on 2008 household survey data to identify beneficiaries for a targeting subsidy scheme in Iran. Based on the findings of this study, setting a cut-off percentile of 40% is expected to provide compensation for almost 70 percent of the poorest households. This will result in the highest accuracy main...

Journal: :Nature Reviews Cancer 2020

Journal: :Digestive Diseases and Sciences 2015

2014
Shuo Gu Yue Zhang Lan Jin Yong Huang Feijie Zhang Michael C. Bassik Martin Kampmann Mark A. Kay

The use of RNA interference is becoming routine in scientific discovery and treatment of human disease. However, its applications are hampered by unwanted effects, particularly off-targeting through miRNA-like pathways. Recent studies suggest that the efficacy of such off-targeting might be dependent on binding stability. Here, by testing shRNAs and siRNAs of various GC content in different gui...

Journal: :iranian journal of economic studies 2013
mohammad bakhshoodeh

in this paper i develop a proxy means tests (pmt) model and examine several targeting lines based on 2008 household survey data to identify beneficiaries for a targeting subsidy scheme in iran. based on the findings of this study, setting a cut-off percentile of 40% is expected to provide compensation for almost 70 percent of the poorest households. this will result in the highest accuracy main...

Journal: :Blood 2012
Leo I Gordon Richard Longnecker

We now think of classical Hodgkin lymphoma (cHL) as derived from "crippled" germinal center B cells that have frequently acquired rearranged and somatically mutated Ig genes.1,2 Despite their B-cell origin, the malignant Hodgkin and Reed-Sternberg (HRS) cells have lost most of the superficial trappings of B cells and therefore have been hidden from investigators' lenses for decades, prompting a...

2010
Jesper B. Bramsen Malgorzata M. Pakula Thomas B. Hansen Claus Bus Niels Langkjær Dalibor Odadzic Romualdas Smicius Suzy L. Wengel Jyoti Chattopadhyaya Joachim W. Engels Piet Herdewijn Jesper Wengel Jørgen Kjems

Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function in mammalian cells yet trigger unintended gene silencing due to their inherent miRNA-like behavior. Such off-target effects are primarily mediated by the sequence-specific interaction between the siRNA seed regions (position 2-8 of either siRNA strand counting from the 5'-end) and complementary se...

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