Pain management and opioid consumption after distal radius fracture (DRF) open reduction and internal fixation (ORIF) are highly variable and poorly understood. To optimize postoperative opioid dosage and better understand opioid consumption patterns after DRF-ORIF, we conducted a prospective study with the hypothesis that opioid consumption would increase with worsening fracture classification...

infusion as demonstrated in Figure 3 in our article. Opioid consumption on the other hand is an indirect measure of pain intensity. We agree that PCB is associated with an opioid-sparing effect, and therefore a lower cumulative opioid intake after surgery. Our review shows significantly lower opioid consumption up to 24 h after surgery. Cumulative opioid consumption, however, provides no inform...

BACKGROUND The increased consumption of analgesics has been documented worldwide during the last 2 decades. The aim of the study was to examine the trends in opioid and nonopioid analgesic consumption in Croatia between 2007 and 2013. METHODS Data on opioid consumption were extracted from the database of the national authority. All opioid and nonopioid analgesics were included in the analysis...

Opioid signaling in the nucleus accumbens (NAcc) strongly modulates flavor-based food choice. To further investigate the role of opioid signaling in taste reward, we used a sensory specific satiety (SSS) paradigm to devalue specific flavors of nutritionally identical food pellets in rats. In the NAcc, infusion of a mu opioid (MOP) receptor selective agonist selectively increased consumption of ...

PURPOSE Prescription opioid misuse has become increasingly prevalent in the United States. Preoperative opioid counseling has been proposed to decrease opioid consumption after surgery. This study aimed to evaluate the effect of preoperative opioid counseling on patients' pain experience and opioid consumption after carpal tunnel release (CTR) surgery. METHODS A prospective comparison of cons...

Opioid signaling in the nucleus accumbens (NAcc) regulates feeding behavior, having particularly strong effects on consumption of highly palatable foods. Since macronutrient content may contribute to palatability, it is uncertain whether opioid regulation of food consumption is based primarily on its macronutrient content or its flavor per se. In order to isolate the effect of flavor, we manipu...

AIMS To examine concurrent buprenorphine and benzodiazepine consumption and to compare opioid toxicity symptoms induced by methadone and buprenorphine, examining factors associated with the reporting of these symptoms. DESIGN Self-report cross-sectional survey. SETTING Five needle syringe programmes and five opioid substitution treatment services in Melbourne, Australia. PARTICIPANTS A to...

INTRODUCTION: In response to a growing opioid crisis, there is an increased focus on reducing opioid consumption perioperatively. Pectoral nerve blocks (Pecs blocks) have previously been shown to successfully manage postoperative pain in mastectomy patients, decreasing perioperative opioid consumption and postoperative nausea. Over the past several years, we have begun incorporating Pecs blocks...

There is increasing evidence supporting a link between the endogenous opioid system and excessive alcohol consumption. Acute or light alcohol consumption stimulates the release of opioid peptides in brain regions that are associated with reward and reinforcement and that mediate, at least in part, the reinforcing effects of ethanol. However, chronic heavy alcohol consumption induces a central o...

INTRODUCTION: In response to a growing opioid crisis, there is an increased focus on reducing opioid consumption perioperatively. Pectoral nerve blocks (Pecs blocks) have previously been shown to successfully manage postoperative pain in mastectomy patients, decreasing perioperative opioid consumption and postoperative nausea. Over the past several years, we have begun incorporating Pecs blocks...