Unintentional poisoning is the most common challenge during childhood age. Among them organophosphate, commonly used insecticide agent related to in children. Organophosphate causes up 25% of mortality worldwide. The present article discusses case a 3 year old child with accidental intake organophosphate revealing symptoms experienced by patient and different treatment modalities employed its o...

BACKGROUND Previous studies stating a high prevalence of occupational acute pesticide poisoning in developing countries have mainly relied on measurements of the rather non-specific self-reported acute pesticide poisoning symptoms. Only a few studies have measured the biomarker plasma cholinesterase (PchE) activity, in addition to the symptoms, when assessing occupational acute pesticide poison...

OBJECTIVE To review the public health significance of organophosphate pesticide exposure in the United States of America. Since the situation of high organophosphate pesticide exposure and the concomitant health risks in the developing countries of the world is well known, this article seeks to highlight the public health significance of organophosphate exposure in the United States, where it i...

introduction: organophosphate compounds are used as insecticides, nerve gases, ophthalmic agents, and antihelmintics.the primary mechanism of action of organophosphate pesticides is inhibition of acetylcholinesterase (ache). however  pralidoxim has been introduced as organophosphate `s antidote but recent studies establish that pralidoxim has unclear benefit in treatment of organophosphate pois...

Organophosphate pesticides are widely used and recent studies suggest associations of in utero exposures with adverse birth outcomes and neurodevelopment. Few studies have characterized organophosphate pesticides in human plasma or established how these levels correlate to urinary measurements. We measured organophosphate pesticide metabolites in maternal urine and chlorpyrifos and diazinon in ...

BACKGROUND Many patients with organophosphate poisoning require mechanical ventilation. Muscle acetylcholinesterase (AChE) activity determines the impairment of muscle force generation, and red blood cell (RBC) AChE has been regarded as a surrogate for muscle AChE in organophosphate poisoning. Therefore, this study was conducted to investigate whether RBC AChE at presentation can predict the du...

introduction: compounds which are used to treat organophosphate (op) poisoning are not able to fully alleviate long lasting effects. they are mainly used to antagonize cholinergic effects of ops. however, non-cholinergic effects, such as interference with different neurotransmitter systems, especially gaba release and uptake, are recently attracting more attentions. we have tried to investigate...

OBJECTIVES Poisoning by organophosphate insecticides causes cholinergic toxicity. Organophosphate induced delayed polyneuropathy (OPIDP) is a sensory-motor distal axonopathy which usually occurs after ingestion of large doses of certain organophosphate insecticides and has so far only been reported in patients with preceding cholinergic toxicity. Surprisingly, it was recently reported by other ...

Background Farmers in developing countries use highly toxic organophosphate pesticides. Thus, the aim of this study was to compare plasma cholinesterase (PChE) enzyme activity before and after exposure to organophosphate pesticides in a real-life setting. Methods This was a prospective study conducted on 25 farmers spraying organophosphate pesticide in their farm. The PChE level was measured ...

Organophosphate poisoning is characterised for the most part, by acute incidents. Management is by way of first aid (in mild poisoning) and use of atropine with or without the oximes, (in moderate to severe poisoning). Of late, it has become apparent that subchronic and chronic organophosphate poisoning are a common manifestation. This review paper summarises this triphasic nature of organophos...