background: dysmenorrhea which means menstrual pain is the most common complaint in women and is one of the problems of health care. iranian traditional medicine (itm) considers dysmenorrhea as osre-tams and mentha longifolia has been indicated as one of the plants that is effective for its treatment. the objective of this study is to evaluate the effect of mentha longifolia on patients with se...

Background: Dysmenorrhea which means menstrual pain is the most common complaint in women and is one of the problems of health care. Iranian Traditional medicine (ITM) considers dysmenorrhea as Osre-Tams and Mentha Longifolia has been indicated as one of the plants that is effective for its treatment. The objective of this study is to evaluate the effect of Mentha Longifolia on...

Support Vector Machines (SVM) are believed to be as powerful as Artificial Neural Networks (ANN) in modeling complex problems while avoiding some of the drawbacks of the latter such as local minimæ or reliance on architecture. However, a question that remains to be answered is whether SVM users may expect improvements in the interpretability of their models, namely by using rule extraction meth...

Tannic acid-templated mesoporous silica (TAMS) was synthesized using a simple nonsurfactant template method and dopamine-functionalized TAMS (Dop-TAMS), which was prepared via a biomimetic coating, was developed as a new support for immobilization of NHase (NHase@Dop-TAMS). The Dop-TAMS was thoroughly characterized by the transmission electron microscopy (TEM), scanning electron microscopy (SEM...

Tumor-associated macrophages (TAMs) play a role in tumor development and progression. We hypothesized that abundance of TAMs might modify efficacy of 5-fluorouracil chemotherapy in colorectal cancer. We measured the density of CD68+ TAMs at the invasive front of primary tumor of colorectal carcinoma (PT-TAMs; n = 208), at available matched metastatic lymph node (LN-TAMs; n = 149), and in an ind...

Accumulating evidences postulated the influential roles of macrophages in mediating hepatocellular carcinoma (HCC) initiation and progression. In this study, we demonstrate that a small molecule, genipin reduced HCC growth through suppressing IRE1α-mediated infiltration and priming of tumour associated macrophages (TAMs). Oral administration of genipin (30mg/kg/2days) suppressed orthotopic HCC ...

Tumor-associated macrophages (TAMs) and regulatory T cells (Tregs) are significant components of the microenvironment of solid tumors in the majority of cancers. TAMs sequentially develop from monocytes into functional macrophages. In each differentiation stage, TAMs obtain various immunosuppressive functions to maintain the tumor microenvironment (e.g., expression of immune checkpoint molecule...

CD163+ tumor-associated macrophages (TAMs) play an important role in the progression of cancer. However, the significance of CD163+ TAMs in malignant pleural effusion (MPE) is still unclear. The aim of this study is to evaluate the prognostic value of CD163+ TAMs in MPE, and the regulatory effect of an immune adjuvant (pseudomonas aeruginosa - mannose-sensitive hemagglutinin, PA-MSHA, which is ...

PURPOSE Tumor associated macrophages (TAMs) are important prognostic factors and have been proved to be associated with the invasion and migration of various cancer. However, the relationship between TAMs and breast cancer outcomes remains unclear. EXPERIMENTAL DESIGN Sixteen studies with a total of 4,541 breast cancer patients were included in this meta-analysis. Correlation of TAMs with ove...

Macrophage colony-stimulating factor (M-CSF) is an important cytokine for monocyte/macrophage lineage. Secretory M-CSF (sM-CSF) and membrane-bound M-CSF (mM-CSF) are two major alternative splicing isoforms. The functional diversity of these isoforms in the activation of tumor-associated macrophages (TAMs), especially in lymphoma microenvironment, has not been documented. Here, we studied the ef...