نتایج جستجو برای: Ovarian Organ Culture

تعداد نتایج: 454686  

Journal: :modares journal of medical sciences: pathobiology 2013
mojde pajokh mojdeh salehnia

objective: growth differentiation factor 9b (gdf9b) is an oocyte-derived growth factor. this protein is essential for the development of ovarian follicles and acts mainly by binding to its receptor on the surface of granulosa cells. the effect of gdf9b on the growth of follicles in various developmental stages, particularly primordial and primary follicles, is unknown. thus the aim of this stud...

The aim of this study was to evaluate the effects of ovarian tissue vitrification and two-step in vitro culture on the metaphase II (MII) oocyte reactive oxygen species (ROS) level, mitochondrial transcription factor A (TFAM) expression and succinate dehydrogenase (SDH) activity. After collection of neonatal mouse ovaries, 45 ovaries were vitrified and the others (n = 45) were...

2013
Tyvette S. Hilliard Dimple A. Modi Joanna E. Burdette

Ovarian cancer is the most lethal gynecological malignancy affecting American women. The gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH), have been implicated as growth factors in ovarian cancer. In the present study, pathways activated by FSH and LH in normal ovarian surface epithelium (OSE) grown in their microenvironment were investigated. Gonadotropins increas...

Journal: :Journal of reproduction and fertility 1973
R M Moor

Ovarian follicles are a major site of oestrogen synthesis in sheep, but almost nothing is known about the relative contribution made by follicles of different sizes to the output of oestrogen at various stages of the reproductive cycle. To determine this, ovaries were dissected from sheep, all follicles over 2 mm in diameter were explanted separately as organ cultures and the daily production o...

Journal: :Frontiers in bioscience : a journal and virtual library 2002
P J Devine K S Rajapaksa Patricia B Hoyer

Many investigations have utilized techniques for culturing ovarian tissue or isolated follicles in vitro. Whole ovaries from fetal or neonatal rodents have been incubated in organ culture systems. This has been utilized to understand the sequence of follicle formation and its hormonal requirements, activation of quiescent follicles, follicular growth and development, and acquisition of steroido...

Journal: :Reproduction 2006
Inger B Carlsson Mika P E Laitinen Jennifer E Scott Henna Louhio Louiza Velentzis Timo Tuuri Johanna Aaltonen Olli Ritvos Robert M L Winston Outi Hovatta

The receptor tyrosine c-Kit and its cognate ligand, c-Kit ligand (KL, stem cell factor, SCF), are involved in ovarian follicular development in several animal species. We studied the expression of KL and c-Kit using in situ hybridization and immunohistochemistry in donated human ovarian cortical tissue. The KL transcripts were expressed in granulosa cells of primary follicles, whereas the expre...

2017
Alon Kedem Anate Aelion-Brauer Peipei Guo Duancheng Wen Bi-Sen Ding Raphael Lis Du Cheng Vladislav M. Sandler Shahin Rafii Zev Rosenwaks

BACKGROUND New data suggests that endothelial cells (ECs) elaborate essential "angiocrine factors". The aim of this study is to investigate the role of activated ovarian endothelial cells in early in-vitro follicular development. METHODS Mouse ovarian ECs were isolated using magnetic cell sorting or by FACS and cultured in serum free media. After a constitutive activation of the Akt pathway w...

Journal: :avicenna journal of medical biotechnology 0

background: the basal medium that supports isolated mouse oviduct (imo) is important for supporting embryo development and quality. methods: the culture of ovine ivm/ivf zygotes was done in imo using sofaacibsa and sofaabsa as basal medium of imo and in sofaabsa alone as control. for preparation of imo mature inbred strain c57bl/6 female mice were synchronized and mated with vasectomized males....

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