BACKGROUND AND OBJECTIVES Oxidant damage is an important contributor to the premature destruction of erythrocytes and anemia in thalassemias. To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of human beta-thalassemia intermedia (b1/b2 deletion). DESIGN AND METHODS Several ...

RATIONALE Even though oxidative stress has been proposed as an underlying mechanism for the symptoms in patients with obstructive sleep apnoea syndrome (OSAS), little information is available on the effects of anti-oxidant treatment on their improvement. OBJECTIVES To observe the effects of anti-oxidant treatment on polysomnographic parameters and oxidative stress markers in OSAS patients. ...

BACKGROUND Hemodynamically significant patent ductus arteriosus (hsPDA) leads to injury in tissues/organs by reducing perfusion of organs and causing oxidative stress. The purpose of this study was to evaluate the oxidant/antioxidant status in preterm infants with hsPDA by measuring the total antioxidant capacity and total oxidant status and to assess neuronal damage due to oxidant stress relat...

In many cancers, a chronic increase in oxidant stress - associated with elevated levels of hydrogen peroxide - contributes to the increased proliferative rate, diminished apoptosis, increased angiogenic and metastatic capacity, and chemoresistance that often characterize advanced malignancies. This oxidant stress often reflects up-regulation of expression and activity of NADPH oxidase, and/or d...

Nanomaterials are capable of generating reactive oxygen species (ROS) due to defect-induced electronic interactions with and water stimulated by environmental structural factors (e.g., photonic energy, band edge morphology) resulting in excellent pro-oxidant activity nanomaterials. The activities demonstrated the antibacterial nanomaterials under different conditions varying light levels). This...

Ozone (O3) is a natural gaseous molecule made up of three oxygen atoms. It leads to lyses the cell membrane most bacteria that causes dental problems due its oxidant and oxidizer properties. therapy opens new vista in treatment atraumatic, biologically based treatment. This review explores use ozone dentistry.

We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac mo...