introduction: busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. the aim of this study was to assess antioxidant status, reactive oxygen species (ros) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. materials and methods: forty adult nmri mice (30 ± 5 g) were divided into t...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...

introduction: perepubertal varicocele can result in hypotrophy of testes, sperm damage and decrease the function of leydig cells in future. pathophysiology of varicocele is unclear. increased reactive oxygen species (ros) is a major theory. there are many controversies in treatment of pediatric varicocele. flaxseed (fs) is the richest source of lignans with antioxidant properties. the aim of th...

by producing reactive oxygen and nitrogen species, metal-induced toxicity and carcinogenicity alter dna bases, increase  lipid peroxidation, and change calcium and sulfhydryl homeostasis. the purpose of the study was to investigate putative effects of lemon balm and cinnamomum zeylanicum on the blood markers of welding workers. we measured nickel and chromium levels, biochemical parameters, blo...

background: this study was performed to investigate the adverse effects of acute lead intoxication on hemogram, erythrocyte osmotic fragility and oxidant/antioxidant status and the probable ameliorating effect of silymarin in comparison to d-penicillamine. methods: forty-eight albino rats were divided in 8 groups and received the following treatments in a 10 day experiment in shahid chamran uni...

background: arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders. the present investigation has been conducted in adult male rats to evaluate the protective ability of α-lipoic acid (ala) against such hematological disorders. methods: twenty-four adult male wister rats (b.wt.130±10g) we...

oxidation of low density lipoprotein (ldl) particles plays a key role in the etiology of atherosclerosis and coronary artery disease (cad). oxidative stress enhances the likelihood of ldl oxidation and atherosclerotic plaque development. paraoxonase (poni) is an enzyme associated with hdl that metabolizes organophosphates and has antioxidant activity. in order to investigate the relationship be...

the metabolic syndrome (ms) recognized as a major cause of type 2 diabetes and cardiovascular diseases, has become one of the major public health challenges worldwide. the pathogenesis of the metabolic syndrome is multiple and still poorly understood. no single factor has yet been identified as an underlying causal factor. there is a growing belief, however, that obesity, specially visceral obe...

background: the effects of estrogene on central nervous system are still controversial. objective: we aimed to investigate the effects of raloxifene on the antioxidant enzyme [superoxide dismutase (sod) and catalase (cat)] activities and malondialdehyde (mda) levels in brain homogenates of ovariectomized female rats and its effect on cognitive process of learning. materials and methods: female ...

background: high content of phospholipids in testes and epididymis is involved in regulation of spermatogenesis. on the other side, it makes testes susceptible to oxidative stress due to lipid peroxidation, which alters the normal mechanism of spermatogenesis. objective: in the present investigation, antioxidant effects of ethanolic extracts of parsley, lettuce and brahmi were tested against d-...