نتایج جستجو برای: P. berghei

تعداد نتایج: 1271033  

Journal: :Infection and immunity 2016
Luciana V de Moraes Sebastien Dechavanne Patrícia M Sousa André Barateiro Sónia F Cunha Sofia Nunes-Silva Flávia A Lima Oscar Murillo Claudio R F Marinho Stephane Gangnard Anand Srivastava Joanna A Braks Chris J Janse Benoit Gamain Blandine Franke-Fayard Carlos Penha-Gonçalves

Plasmodium falciparum infection during pregnancy leads to abortions, stillbirth, low birth weight, and maternal mortality. Infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) via var2CSA protein exposed on the P. falciparum IE membrane. Plasmodium berghei IE infection in pregnant BALB/c mice is a model for severe placental malaria (PM). Here, we des...

2017
John M. Pisciotta Peter F. Scholl Joel L. Shuman Vladimir Shualev David J. Sullivan

The incidence and global distribution of chloroquine resistant (CR) Plasmodium vivax infection has increased since emerging in 1989. The mechanism of resistance in CR P. vivax has not been defined. The resistance likely relates to the formation and disposition of hemozoin as chloroquine's primary mechanism of action involves disruption of hemozoin formation. CR P. berghei strains, like CR P. vi...

2010
Shigeto Yoshida Hiroshi Nagumo Takashi Yokomine Hitomi Araki Ayaka Suzuki Hiroyuki Matsuoka

BACKGROUND Two current leading malaria blood-stage vaccine candidate antigens for Plasmodium falciparum, the C-terminal region of merozoite surface protein 1 (MSP1(19)) and apical membrane antigen 1 (AMA1), have been prioritized because of outstanding protective efficacies achieved in a rodent malaria Plasmodium yoelii model. However, P. falciparum vaccines based on these antigens have had disa...

Journal: :Infection and immunity 2012
Juliana V Harris Tiffany M Bohr Catherine Stracener Mary E Landmesser Vladimir Torres Amos Mbugua Chantal Moratz José A Stoute

Lack of an adequate animal model of Plasmodium falciparum severe malarial anemia (SMA) has hampered the understanding of this highly lethal condition. We developed a model of SMA by infecting C57BL/6 mice with P. chabaudi followed after recovery by P. berghei infection. P. chabaudi/P. berghei-infected mice had an initial 9- to 10-day phase of relatively low parasitemia and severe anemia, follow...

2013
Anna L. Goodman Emily K. Forbes Andrew R. Williams Alexander D. Douglas Simone C. de Cassan Karolis Bauza Sumi Biswas Matthew D. J. Dicks David Llewellyn Anne C. Moore Chris J. Janse Blandine M. Franke-Fayard Sarah C. Gilbert Adrian V. S. Hill Richard J. Pleass Simon J. Draper

Rodent malaria species Plasmodium yoelii and P. chabaudi have been widely used to validate vaccine approaches targeting blood-stage merozoite antigens. However, increasing data suggest the P. berghei rodent malaria may be able to circumvent vaccine-induced anti-merozoite responses. Here we confirm a failure to protect against P. berghei, despite successful antibody induction against leading mer...

2016
Mariana De Niz Ann-Katrin Ullrich Arlett Heiber Alexandra Blancke Soares Christian Pick Ruth Lyck Derya Keller Gesine Kaiser Monica Prado Sven Flemming Hernando Del Portillo Chris J Janse Volker Heussler Tobias Spielmann

Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. falciparum proteins known to be involved in this process are conserved in the rodent...

Journal: :Infection and immunity 1999
T Yoneto T Yoshimoto C R Wang Y Takahama M Tsuji S Waki H Nariuchi

We have examined the roles of gamma interferon (IFN-gamma), nitric oxide (NO), and natural killer (NK) cells in the host resistance to infection with the blood-stage malarial parasite Plasmodium berghei XAT, an irradiation-induced attenuated variant of the lethal strain P. berghei NK65. Although the infection with P. berghei XAT enhanced NK cell lytic activity of splenocytes, depletion of NK1.1...

Journal: :PLoS ONE 2008
Michelle M. Riehle Jiannong Xu Brian P. Lazzaro Susan M. Rottschaefer Boubacar Coulibaly Madjou Sacko Oumou Niare Isabelle Morlais Sekou F. Traore Kenneth D. Vernick

BACKGROUND We previously identified by genetic mapping an Anopheles gambiae chromosome region with strong influence over the outcome of malaria parasite infection in nature. Candidate gene studies in the genetic interval, including functional tests using the rodent malaria parasite Plasmodium berghei, identified a novel leucine-rich repeat gene, APL1, with functional activity against P. berghei...

Journal: :Infection and immunity 2003
Wun-Ling Chang Jie Li Guang Sun Hong-Li Chen Robert D Specian Seth Mark Berney D Neil Granger Henri C van der Heyde

Plasmodium berghei-infected mice, a well-recognized model of experimental cerebral malaria (ECM), exhibit many of the hallmarks of a systemic inflammatory response, with organ damage in brain, lung, and kidneys. Identification of the molecules mediating pathogenesis of the inflammatory response, such as leukocyte adhesion, may lead to new therapies. Indeed, mice lacking the cell adhesion molecu...

Journal: :PloS one 2016
Cristina K Moreira Bernina Naissant Alida Coppi Brandy L Bennett Elena Aime Blandine Franke-Fayard Chris J Janse Isabelle Coppens Photini Sinnis Thomas J Templeton

The phist gene family has members identified across the Plasmodium genus, defined by the presence of a domain of roughly 150 amino acids having conserved aromatic residues and an all alpha-helical structure. The family is highly amplified in P. falciparum, with 65 predicted genes in the genome of the 3D7 isolate. In contrast, in the rodent malaria parasite P. berghei 3 genes are identified, one...

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