نتایج جستجو برای: P53 signaling pathways

تعداد نتایج: 504371  

Journal: :iranian journal of basic medical sciences 0
song liu department of respiratory medicine, xinhua hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china, 200092 zhonghua wang department of medical oncology, fudan university shanghai cancer center; department of oncology, shanghai medical college, fudan university, shanghai, china, 200032 kui chen department of neurology, beijing friendship hospital, capital medical university, beijing, china, 100050 kui chen department of neurology, beijing friendship hospital, capital medical university, beijing, china, 100050 jinyuan sun department of respiratory medicine, xinhua hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china, 200092 lianping ren department of respiratory medicine, xinhua hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china, 200092

objective(s):intermittent hypoxia (ih), caused by obstructive sleep apnea (osa), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. thus, the present study aimed to explore the effect of ih on the biological functions of microglia cells. materials and methods:cell proliferation of bv2 cells after exposure to ih were o...

Bo Xu, Jinyuan Sun Kui Chen, Lianping Ren Song Liu, Zhonghua Wang

Objective(s):Intermittent hypoxia (IH), caused by obstructive sleep apnea (OSA), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. Thus, the present study aimed to explore the effect of IH on the biological functions of microglia cells. Materials and Methods:Cell proliferation of BV2 cells after exposure to IH were o...

The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)in China threatened humankind worldwide. The coronaviruses contains the largest RNA genome among all other known RNA viruses, therefore the disease etiology can be understood by analyzing the genome sequence of SARS-CoV-2. In this study, we used an ab-intio based computational tool VMir to scan the complete geno...

Journal: :gastroenterology and hepatology from bed to bench 0
hakimeh zali faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran mostafa rezaei-tavirani proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran reza vafaee proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran majid rezaei-tavirani faculty of medicine, ilam university of medical sciences, ilam, iran

gastric cardia adenocarcinoma (gca)is one of the few malignancies with unexplained reasons that have increased sharply in developed countries. the purpose of this review was to determine the pathways in gca to identify new biomarker. so by comparing gene expression in gca group with normal control identified important pathways. gene expression data were extracted from the beforehand investigati...

Journal: :Nature Communications 2021

Abstract Genotoxic colibactin-producing pks + Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected human CRC, suggesting a causal link. Here, we investigate its transformation potential using organoids from primary murine colon epithelial cells. Organoids rec...

Journal: :Cancers 2023

p53 plays a critical role in tumor suppression and is the most frequently mutated gene human cancers. Most mutants (mutp53) are missense mutations thus expressed In cancers that retain wtp53, wtp53 activities downregulated through multiple mechanisms. For example, overexpression of negative regulators p53, MDM2/MDMX, can also efficiently destabilize inactivate wtp53. Therefore, both mutp53 have...

2017
Annapina Russo Giulia Russo

The nucleolus is the site of ribosome biogenesis, a complex process that requires the coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that participate in the maturation of ribosomal RNA (rRNA) and assembly of small and large subunits. Nevertheless, emerging studies have highlighted the fundamental role of the nucleolus in sensing a variety of cellular stre...

Journal: :Cancer research 1996
C Y Chen I Hall T J Lansing T M Gilmer T D Tlsty M B Kastan

The tumor suppressor gene product, p53, appears to be a significant participant in signaling pathways that mediate cellular responses to cytotoxic stresses. In particular, p53 appears to be a critical determinant of whether the cell lives or dies and how it progresses through the cell cycle after the cytotoxic exposure. Many of the molecular details for these signaling pathways remain to be elu...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

Journal: :Molecular and cellular biology 2005
Jamie M Hearnes Deborah J Mays Kristy L Schavolt Luojia Tang Xin Jiang Jennifer A Pietenpol

In various human diseases, altered gene expression patterns are often the result of deregulated gene-specific transcription factor activity. To further understand disease on a molecular basis, the comprehensive analysis of transcription factor signaling networks is required. We developed an experimental approach, combining chromatin immunoprecipitation (ChIP) with a yeast-based assay, to screen...

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