Hydrogels, electrospun fiber mats (EFMs), and their composites have been extensively studied for tissue engineering because of their physical and chemical similarity to native biological systems. However, while chemically similar, hydrogels and electrospun fiber mats display very different topographical features. Here, we examine the influence of surface topography and composition of hydrogels,...

Hydrogen peroxide is one of the fundamental molecules of biology, regulating key cell signaling pathways and the development of numerous inflammatory diseases. There is therefore great interest in developing contrast agents that can detect hydrogen peroxide in vitro and in vivo. In this report, we present a new contrast agent for imaging hydrogen peroxide, termed the chemiluminescent poly(ethyl...

Achieving stable, long-term performance of implanted neural prosthetic devices has been challenging because of implantation related neuron loss and a foreign body response that results in encapsulating glial scar formation. To improve neuron-prosthesis integration and form chronic, stable interfaces, we investigated the potential of neurotrophin-eluting hydrogel-electrospun fiber mat (EFM) comp...

Magnetic cellulose nanocrystals (MCNCs) were prepared and used as an enzyme support for immobilization of Pseudomonas cepacialipase (PCL). PCL was successfully immobilized onto MCNCs (PCL@MCNC) by a precipitation-cross-linking method. The resulting PCL@MCNC with a nanoscale size had high enzyme loading (82.2 mg enzyme/g) and activity recovery (95.9%). Compared with free PCL, PCL@MCNC exhibited ...

polycaprolactone (pcl) and poly(butylene terephthalate) (pbt) blend was prepared by melt processing. the pcl/pbt blend showed similar morphology with that of pure pcl.the crystallization temperature of pcl was increased by the incorporation of pbt. it was also observed that the peak height in the dsc thermograms decreased and then disappeared by adding 40 % or more pbt which might be due to the...

Biocomposite scaffolds were fabricated by incorporation of nanobredigite (n-BD) into the polymer of poly(ε-caprolactone)-poly(ethyleneglycol)-poly(ε-caprolactone) (PCL-PEG-PCL). The results revealed that the addition of n-BD into PCL-PEG-PCL significantly improved water absorption, compressive strength, and degradability of the scaffolds of n-BD/PCL-PEG-PCL composite (n-BPC) compared with PCL-P...

Star-shaped polymer micelles have good stability against dilution with water, showing promising application in drug delivery. In this work, biodegradable micelles made from star-shaped poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer were prepared and used to deliver doxorubicin (Dox) in vitro and in vivo. First, an acrylated monomethoxy poly (ethylene glycol)-poly(ε-caprolactone)...

BACKGROUND In this study, we examined two polycaprolactone (PCL)-based dermal filler formulas (PCL-1; PCL-2) for safety, patient satisfaction, likelihood to return, efficacy, and duration of correction. OBJECTIVE This 40-patient, 24-month, prospective, randomized, controlled study evaluated the efficacy, safety, longevity, and volume of two PCL formulas for correction of nasolabial folds. M...

Scaffolds for cartilage tissue engineering should promote both adequate biomechanical environment and chondrogenic stimulation. Hyaluronic acid (HA) has been used in cartilage engineering for its chondrogenic and chondroprotective properties, nevertheless its mechanical properties are limited. Influence of HA microstructure in chondrocyte response has not been addressed yet. In this work, polyc...

Ratio blends of PLGA/PCL: (0:10), (1:9), (2:8), (3:7), (4:6), (5:5), (6:4), (7:3), (8:2), (9:1), and (10:0) were spin-coated to produce thin films; surface topographies were determined using interferometric microscopy. It was demonstrated that micro-wells of a defined size (150 mm) were present in all PCL dominant PLGA/PCL systems. Stratification of PLGA with PCL enabled the formation of that s...