Synopsis Although hormonally-derived female sex pheromones have been well described in approximately a dozen species of teleost fish, only few male characterized and the neuroendocrine underpinnings behavioral responsiveness to them is not understood. Herein, we describe study that addresses this question using goldfish, Carassius auratus, an important model how hormones drive behavior egg-layi...

According to the current working classification for prostanoid receptors, the prostaglandin F2 alpha-sensitive receptor (FP-receptor) may be identified by comparing the rank order of activity of prostaglandin F2 alpha (PGF2 alpha) and its analogues. In order to further understand the pharmacology of PGF2 alpha-induced ocular hypotension, the intraocular pressure response to PGF2 alpha and selec...

To examine the response of renal prostaglandins (PG) to systemic and renal vasoconstriction noradrenaline (NA), arginine vasopressin (AVP) and angiotensin II (ANG II) were each infused into eight healthy female subjects for 3 h on different days. Urinary excretion of PGE2, PGF2 alpha and 6-keto-PGF1 alpha was determined hourly. NA and ANG II stimulated excretion of PGF2 alpha significantly, but...

The ability of a number of prostaglandin F2 (PGF2 ) analogs to mobilize intracellular Ca [Ca ]i and to compete for [H]PGF2 binding to prostaglandin F2 receptors (FP) was evaluated. Radioligand binding studies measuring displacement of [H]PGF2 by a variety of FP prostaglandin analogs yielded the following rank order of affinities: travoprost acid [( )-16-m-trifluorophenoxy tetranor PGF2 ; ( )-fl...

The effect of inhaled prostaglandin (PG) F2 alpha on the response to the inhaled tussive agent capsaicin was investigated in normal subjects. Seven subjects inhaled three breaths of four doses of capsaicin (0.3, 0.6, 1.2, and 2.4 nmol) before and immediately after inhaling PGF2 alpha (0.1 mumol) or placebo (0.15M NaCl) on separate days. The numbers of capsaicin induced coughs were greater after...

Prostaglandins (PGs) are known to have effects on hepatic glucose metabolism. Some actions of PGs in intact liver systems may not involve PG effects directly at the level of the hepatocyte. To define the ability of structurally distinct prostaglandins to affect hepatocyte metabolism directly, the regulation of glycogenolysis was studied in hepatocytes isolated from male Sprague-Dawley rats. PGF...

Abstract Background Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated prostaglandin F2? (PGF2?), a potent bone remodeling factor, induces synthesis interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated (MAP) kinase p38 MAP osteoblast-like MC3T3-E1 cell...

We investigated the extent of oxidative stress evoked in the hypertensive rat by measuring plasma levels of 8-epi-prostaglandin F2 (8-epi-PGF2 ), a marker of in vivo oxidative stress. Administration of angiotensin (Ang) II and norepinephrine at doses of 0.7 and 2.8 mg · kg 1 · d , respectively, resulted in similar significant elevations in plasma levels of 8-epi-PGF2 . A 7-day infusion of Ang I...

1. The influence of mental stress, 30 min Kraepelin's arithmetic test under noise on the plasma concentration and urinary excretion of prostaglandin (PG) F2 alpha was studied in patients with essential hypertension and in healthy subjects. 2. Before the arithmetic test the plasma PGF2 alpha in hypertensive patients was significantly higher than in healthy subjects. The mental stress produced a ...

Kim, Nari, Jin Han, and Euiyong Kim. Effects of prostaglandin F2 on membrane currents in rabbit middle cerebral arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 284: H1018–H1027, 2003; 10.1152/ajpheart. 01022.2001.—Although PGF2 affects contractility of vascular smooth muscles, no studies to date have addressed the electrophysiological mechanism of this effect. The purpose of our i...