نتایج جستجو برای: PI3-K/AKT/mTOR- signaling

تعداد نتایج: 299951  

Journal: :Neuron 2000
Rejji Kuruvilla Haihong Ye David D Ginty

NGF is a target-derived growth factor for developing sympathetic neurons. Here, we show that application of NGF exclusively to distal axons of sympathetic neurons leads to an increase in PI3-K signaling in both distal axons and cell bodies. In addition, there is a more critical dependence on PI3-K for survival of neurons supported by NGF acting exclusively on distal axons as compared to neurons...

Journal: :American journal of physiology. Renal physiology 2004
Qiusheng Tong Rachell E Booth Roger T Worrell James D Stockand

Cross talk between the phosphatidylinositol 3-kinase (PI3-K) and mitogen-activating protein kinase (MAPK)1/2 signaling cascades in response to aldosterone-induced K-RasA was investigated in renal A6 epithelial cells. In addition, the contribution of these signaling pathways to aldosterone-stimulated Na(+) transport was investigated. Aldosterone increased active K-RasA levels in A6 cells resulti...

Journal: :Molecular and cellular biology 2000
R D York D C Molliver S S Grewal P E Stenberg E W McCleskey P J Stork

Neurotrophins promote multiple actions on neuronal cells including cell survival and differentiation. The best-studied neurotrophin, nerve growth factor (NGF), is a major survival factor in sympathetic and sensory neurons and promotes differentiation in a well-studied model system, PC12 cells. To mediate these actions, NGF binds to the TrkA receptor to trigger intracellular signaling cascades. ...

2004
Qiusheng Tong Rachell E. Booth Roger T. Worrell James D. Stockand Antonio

Tong, Qiusheng, Rachell E. Booth, Roger T. Worrell, and James D. Stockand. Regulation of Na transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades. Am J Physiol Renal Physiol 286: F1232–F1238, 2004. First published March 23, 2004; 10.1152/ajprenal.00345. 2003.—Cross talk between the phosphatidylinositol 3-kinase (PI3-K) and mitogen-activating prote...

2016
Jared J Barrott Lisa A Kafchinski Huifeng Jin Jared W Potter Sarmishta D Kannan Robert Kennedy Tim Mosbruger Wei-Lien Wang Jen-Wei Tsai Dejka M Araujo Ting Liu Mario R Capecchi Alexander J Lazar Kevin B Jones

Solid tumor metastasis is a complex biology, impinged upon by a variety of dysregulated signaling pathways. PI3'-lipid signaling has been associated with metastasis and inflammation in many cancers, but the relationship between tumor cell-intrinsic PI3'-lipid signaling and inflammatory cell recruitment has remained enigmatic. Elevated PI3'-lipid signaling associates with progression of synovial...

Journal: :Molecular endocrinology 2002
Takayuki Kamei Stephanie R Jones Belinda M Chapman Kerry L MCGonigle Guoli Dai Michael J Soares

Activation of Lyn, a Src-related nonreceptor tyrosine kinase, in trophoblast cells is associated with trophoblast giant cell differentiation. The purpose of the present work was to use Lyn as a tool to identify signaling pathways regulating the endocrine differentiation of trophoblast cells. The Src homology 3 domain of Lyn was shown to display differentiation-dependent associations with other ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
David Maag Micah J Maxwell Douglas A Hardesty Katie L Boucher Namrata Choudhari Adam G Hanno Jenny F Ma Adele S Snowman Joseph W Pietropaoli Risheng Xu Phillip B Storm Adolfo Saiardi Solomon H Snyder Adam C Resnick

The second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)), formed by the p110 family of PI3-kinases, promotes cellular growth, proliferation, and survival, in large part by activating the protein kinase Akt/PKB. We show that inositol polyphosphate multikinase (IPMK) physiologically generates PIP(3) as well as water soluble inositol phosphates. IPMK deletion reduces growth factor-...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2008
Mei-Lun Wang Sue A Keilbaugh Tanesha Cash-Mason Xi C He Linheng Li Gary D Wu

In the intestinal epithelium, activation of phosphatidylinositol 3-kinase (PI3-kinase)/AKT pathways, via growth factor-mediated signaling, has been shown to regulate cell proliferation and inhibit apoptosis. An immune-activated receptor critical for Th2 immune responses, IL-4Ralpha can also activate PI3-kinase via insulin receptor substrate (IRS)-dependent signaling. Here, using the intestinal ...

Journal: :American journal of physiology. Renal physiology 2005
Lenin Mahimainathan Nandini Ghosh-Choudhury Balachandar A Venkatesan Ratna S Danda Goutam Ghosh Choudhury

Epidermal growth factor (EGF) is a potent mitogen for mesangial cells. The mechanism by which EGF induces DNA synthesis is not precisely understood. We investigated the role of phosphatidylinositol (PI)3-kinase in regulating mitogenesis. EGF increased PI3-kinase activity resulting in stimulation of PDK-1 and Akt kinase activities. Blocking of PI3-kinase activity using LY-294002 or adenoviral ex...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
James D Chang Galina K Sukhova Peter Libby Eugenia Schvartz Alice H Lichtenstein Seth J Field Caitlin Kennedy Swetha Madhavarapu Ji Luo Dianqing Wu Lewis C Cantley

Inflammatory cell activation by chemokines requires intracellular signaling through phosphoinositide 3-kinase (PI3-kinase) and the PI3-kinase-dependent protein serine/threonine kinase Akt. Atherosclerosis is a chronic inflammatory process driven by oxidatively modified (atherogenic) lipoproteins, chemokines, and other agonists that activate PI3-kinase. Here we show that macrophage PI3-kinase/Ak...

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