Epidemiological and histopathological studies have indicated that proliferative inflammatory atrophy (PIA) of the prostate is closely associated with the onset and development of prostate cancer (PCa). However, accurate isolation of PIA still remains a difficult matter, as well as high-quality RNA extraction from isolated PIA. These issues generated a lack of molecular evidence to support the m...

This paper summarizes the aims and scope of the PIA (Portable Information Access) project’s PIA-Core system for automatic annotation of documents on the Semantic Web, i.e. the next generation World Wide Web. The focus of the project is to develop a portable information extraction system that can be easily adapted to new domains. PIA has its foundations on three resources: the PIA-Core informati...

$90-$180 in March 1974. It remained at that level until January 1979 when, under a provision of the 1977 amendments, it was raised to a maximum of $230 a month. The amendments also provided that the special minimum PIA be subject to the same automatic cost-of-living increases as regular benefits. Thus, effective June 1979, the highest special minimum PIA is $252.80 per month. Tbe special minimu...

Aiming at a better understanding of the role of A(2A) in temporal lobe epilepsy (TLE), we characterized the effects of the A(2A) antagonist SCH58261 (7-(2-phenylethyl)-5-amino-2(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine) on seizures and neuroprotection in the pilocarpine model. The effects of SCH58261 were further analyzed in combination with the A(1) agonist R-Pia (R(-)-N(6)-(2...

Polysaccharide intercellular adhesin (PIA), also known as poly-N-acetyl-β-(1-6)-glucosamine (PIA/PNAG) is an important component of Staphylococcus aureus biofilms and also contributes to resistance to phagocytosis. The proteins IcaA, IcaD, IcaB, and IcaC are encoded within the intercellular adhesin (ica) operon and synthesize PIA/PNAG. We discovered a mechanism of phase variation in PIA/PNAG ex...

Several countries prescribe or advise government departments and organizations to perform a privacy impact assessment (PIA) if these prepare new projects or change existing ones that involve personal information. A PIA shall summarize what personal information is collected, processed, stored, and distributed in the context of the project. But there is only little support for undertaking a PIA a...

The fairing curves and surfaces are used extensively in geometric design, modeling, industrial manufacturing. However, the majority of conventional approaches, which lack sufficient parameters to improve fairness, based on energy minimization problems. In this study, we develop a novel progressive-iterative approximation method for curve surface generation (fairing-PIA). Fairing-PIA is an itera...

Staphylococcus epidermidis is an opportunistic biofilm-forming pathogen associated with neurosurgical device-related meningitis. Expression of the polysaccharide intercellular adhesin (PIA) on its surface promotes S. epidermidis biofilm formation. Here we investigated the pro-inflammatory properties of PIA against primary and transformed human astrocytes. PIA induced IL-8 expression in a dose- ...