Background: Glaucomatous neuropathy is a type of cell death due to apoptosis. The p53 gene is one of the regulatory genes of apoptosis. Recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (POAG) has been studied in some ethnic groups. This study is the first association analysis of POAG and p53 codon 72 polymorphism in Iranian patients...

there are reports from different countries that some types of glaucoma are associated with blood groups. this cross-sectional study was performed on 400 glaucomatous patients [100 patients in each group of primary open angle glaucoma (poag), chronic angle closure glaucoma (cacg), pseudoexfoliative glaucoma (pexg) and primary congenital glaucoma (pcg)] and 400 blood donors as control group to as...

BACKGROUND Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear. OBJECTIVE To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD ...

In India, mutations in Cytochrome P450 (CYP1B1) are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited in this study. Genomic DNA was is...

BACKGROUND Non-communicable diseases (NCDs) such as hypertension and diabetes are rapidly emerging public health problems worldwide, and they associate with primary open-angle glaucoma (POAG). POAG is the most common cause of irreversible blindness. The most effective ways to prevent glaucoma blindness involve identifying high-risk populations and conducting routine screening for early case det...

OBJECTIVE To investigate the 5-year incidence and progression rate of primary open-angle glaucoma (POAG) in a health-center-based Korean population. METHODS The study population comprised 5,021 subjects who participated in standardized health screening (including non-contact tonometry and fundus photography) at the Gangnam Healthcare Center during the period from January 2005 to December 2006...

PURPOSE Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness on a global level. Researchers have yet to specify the exact mechanisms of POAG; the respective relationships between POAG and elevated intraocular pressure (IOP), as well as optic neuropathy, remain particularly unclear. It is known, however, that the expression profile for some proteins in the aqueous humo...

background: glaucomatous neuropathy is a type of cell death due to apoptosis. the p53 gene is one of the regulatory genes of apoptosis. recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (poag) has been studied in some ethnic groups. this study is the first association analysis of poag and p53 codon 72 polymorphism in iranian patients...

Glaucoma is a complex genetic optic disease characterized by a range of optic neuropathies. There are many subtypes of glaucoma but primary open-angle glaucoma (POAG) associated with elevated intraocular pressure (IOP) is the most prevalent form. Based on the age of diagnosis, POAG is categorized as early-onset POAG or juvenile open-angle glaucoma (JOAG) diagnosed between 10 and 35 years and ad...

Purpose: We compared visual field progression among patients with primary open-angle glaucoma (POAG), normal tension (NTG), and angle-closure (PACG).Methods: A total of 115 POAG, 123 NTG, 92 PACG eyes were retrospectively analyzed. Global VF was evaluated by calculating the changes mean deviations. To examine local deterioration, scotoma enlargement deepening analyzed in superior, inferior arcu...