Expression of POU1F1 gene, a member of the POU homeodomain family of transcription factors, is necessary for normal differentiation, development and survival of three anterior pituitary cell types (thyrotrophs, somatotrophs and lactotrophs) and for the proper expression of growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (TSH) genes and POU1F1 gene itself. Alternative splicing ...

In this study, POU1F1 gene polymorphism was detected in five sheep populations (large-tailed Han, small-tailed Han, Yuxi fat-tailed, Lanzhou large-tailed, and Mongolian sheep), using DNA pooling and sequencing, to provide theoretical basis for the breeding of excellent sheep varieties. Three single-nucleotide polymorphism (SNP) loci of POU1F1 gene were detected in five sheep populations, namely...

POU1F1 is a positive regulator for GH, PRL and TSHβ and its mutations associate with production traits in ruminant animals. We described a DdeI PCR-RFLP method for detecting a silent allele in the goat POU1F1 gene: TCT (241Ser)>TCG (241Ser). Frequencies of D1 allele varied from 0.600 to 1.000 in Chinese 801 goats. Significant associations of DdeI polymorphism with production traits were found i...

specific trait candidate genes are sequenced genes with known biological activity. the effects of pou1f1 and stat5a on milk production traits have been studied in several studies. pou1f1 affects on transcription of prolactin and growth hormone gene, as well as, stat5a is known as a main mediator of growth hormone action on target genes and intracellular mediator of prolactin signaling. since th...

Brief Summary: This paper describes 5 related Karelian Bear Dogs (KBDs) with a canine hypopituitarism phenotype. Genome-wide association analysis (GWAS) and next-generation sequencing revealed homozygous candidate gene defect in POU1F1. The study thus presents novel animal model for human hypopituitarism.

The aim of the study was to determine the effect of pituitary transcription factor 1 (POU1F1, Pit1) and the polymorphism of growth hormone releasing hormone (GHRH) genes on selected pig performance traits. The animals used were the progeny of Polish Landrace × Polish Large White crossbred sows and Polish Landrace, Polish Large White, Duroc or Pietrain boars. Eighteen perfor-mance traits were re...

This study was carried out to investigate the association of POU1F1 (POU domain, class 1, transcription factor 1, Pit1, renamed as POU1F1) gene with backfat thickness (mm), carcass weight (kg), pH, and color values (L(*), a(*), b(*)) in crossbred pigs (Landrace x Yorkshire x Duroc). Frequency of the AA genotype indel was at the highest level (66.67%). Frequency of A allele (0.81) was higher tha...

the purpose of the study was to detect the alui and ddei polymorphisms within pou1f1 gene exon 6 and 3'utr region in turkish sheep breeds, and their association with milk productive traits. jugular blood samples were collected from 50 sakiz, 50 white karaman, and 50 awassi sheep using edta as an anticoagulant. pcr-rflp and sequencing analysis were performed to investigate possible polymorphisms...

The purpose of the study was to detect the AluI and DdeI polymorphisms within POU1F1 gene exon 6 and 3'UTR region in Turkish sheep breeds, and their association with milk productive traits. Jugular blood samples were collected from 50 Sakiz, 50 White Karaman, and 50 Awassi sheep using EDTA as an anticoagulant. PCR-RFLP and sequencing analysis were performed to investigate possible polymorphisms...