OBJECTIVE: Aluminum is a contaminant in all parenteral nutrition solutions. Manufacturers currently label these products with the maximum aluminum content at the time of expiry, but there are no published data to establish the actual measured concentration of aluminum in parenteral nutrition solution products prior to being compounded in the clinical setting. This investigation assessed quantit...

  The immunogenicity of ten different formulations of intranasal diphtheria and tetanus vaccines which containing different absorption enhancers, adjuvants and other excipients were determined in guinea pigs by the serum neutralization (SN) method. From these ten formulations, it was selected four formulations which gave significant immunogenicity in guinea pigs. In order to design the "final f...

Aim: The objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic profile, compatibility with other formulation excipients physico-chemical parameters new drug substance. This could provide important information for design or support need molecular modification. So, in present studies were performed on Glimepiride (GMP) assess i...

Background: Acetaminophen is the most commonly used analgesic and fever-lowering agent that is prescribed in a high percentage of patients. Due to the high prevalence of the administration of this drug, even a small percentage of errors in prescription can be significant and have important implications. The aim of the present study was to determine the frequency of supratherapeutic dosing of ac...

PURPOSE In this research the effect of vitamin B1 and B6 on cyanocobalamin stability in commercial light protected parenteral formulations and upon adding stabilizing agents will be investigated and best formulation composition and proper storage condition will be introduced. METHODS In this research some additives such as co solvents and tonicity adjusters, surfactants, antioxidants and chel...

Preformulation studies regarding a physico-chemical evaluation of memantine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, are presented in this work. This characterization of memantine is pre-required for the formulation of a parenteral solution. The water solubility, the thermal behavior and the chemical stability in aqueous solution, depending on the pH, temperature, UV ...