Experimental investigation of the ultimate resistance of slender, steel-plate girder web panels to combined shear-and-patch loading indicates significant interaction between shear loading and patch loading. However, an existing interaction formula is based on experimental results. Herein, an improved design procedure for slender plate girders subjected to combined shear and patch loading is pro...

the support vector machine (svm) is a relatively new machine learning method which is increasingly being applied to engineering problems and have yielded encouraging results. because of complex behavior of elastoplastic of web panels of plate girders under patch loading, almost none of the proposed methods provides consistent and accurate predictions of patch load capacity. consequently, altern...

this study aims to undertake a statistical study to evaluate the accuracy of nine models that have been previously proposed for estimating the ultimate resistance of plate girders subjected to patch loading. for each model, mean errors and standard errors, as well as the probability of underestimating or overestimating patch load resistance, are estimated and the resultant values are compared o...

in this paper, a sensitivity analysis of artificial neural networks (nns) is presented and employed for estimating the patch load resistance of plate girders subjected to patch loading. to evaluate the accuracy of the proposed nn model, the results are compared with the previously proposed empirical models, so that we can estimate the resistance of plate girders subjected to patch loading. the ...

here we report a novel approach for preparation of a 6-day transdermal drug delivery system (tdds) as treatment for mild to moderate alzheimer’s disease. the spray drying method was used to prepare microparticles containing the anti-alzheimer drug. the content of the drug was determined by high performance liquid chromatography (hplc) method. the morphology and size range of the microparticles ...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

This protocol describes the loading of individual cells with fluorescent probes via patch pipettes. The patch-clamp methodology has been successfully used for single-cell dye labeling in cultured neurons, brain slices, and in vivo preparations. A broad range of dyes can be used with this loading technique. Markers for morphological reconstruction (e.g., Lucifer yellow); ion-sensitive indicator ...

We present microstrip patch antenna loaded with multiple split ring resonator substrate and superstrate. We analyze how the loading of split ring resonator superstrate and substrate can improve the bandwidth compared to the simple microstrip patch antenna and microstrip patch antenna loaded with split ring resonator superstrate. Another important observation is made for multiple split ring reso...