1 Pediatric Oncology Department, Hôpital de la Mère et de l’Enfant, 87042 Limoges, France 2 Adolescent and Pediatric Oncology Department, Institut Curie, 75005 Paris, France 3 Adolescent and Pediatric Oncology Department, Institut Gustave Roussy, 94800 Villejuif, France 4 Pediatric Surgery Department, Hôpital Trousseau, 75012 Paris, France 5 Pediatric Surgery Department, Hôpital Necker-Enfants-...

Pediatric nasopharyngeal carcinoma, also referred to as cavum carcinoma, is a rare pediatric disease with an infrequent incidence rate. We present the case of a pediatric patient with nasopharyngeal cancer who received an adult schedule of concomitant chemotherapy and conformal radiotherapy with a brachytherapy boost. Adult protocols with high radiotherapy doses are not commonly used in pediatr...

There is a growing body of prospective evidence describing an oligometastatic phenotype in adults for whom local metastasis-directed therapy can improve outcomes select patients. However, relative paucity data pediatric patients with disease creates challenges choosing optimal treatment. The purpose this review to evaluate the literature surrounding and treatment, specifically focusing on role ...

Cancer is a major cause of childhood death, with central nervous system (CNS) neoplasms being the second most common pediatric malignancy, following hematological cancer. Treatment of pediatric CNS malignancies requires multimodal treatment using a combination of surgery, chemotherapy, and radiotherapy, and advances in these treatments have given favorable results and longer survival. However, ...

BACKGROUND We investigated how varying the treatment margin and applying hippocampal sparing and proton therapy impact the risk of neurocognitive impairment in pediatric medulloblastoma patients compared with current standard 3D conformal radiotherapy. METHODS We included 17 pediatric medulloblastoma patients to represent the variability in tumor location relative to the hippocampal region. T...

abstract objective: several studies have been published on the epidemiology of childhood malignancies worldwide. the primary objective of this study is to determine the relative frequency of pediatric cancers in iran. methods: using a retrospective approach, all confirmed cases of malignancies aged 14 years old or less at the time of first referral to the department of radiation oncology of jor...

Background : To assess feasibility of sparing the neural stem cell compartment (NSC), hippocampus, and limbic circuit during partial brain radiotherapy (PBRT) for pediatric intracranial tumors. Methods : Treatment plans were generated for the following pediatric intracranial tumors: low and high grade gliomas, low grade brainstem glioma, optic nerve glioma, hypothalamic glioma, localized ependy...