d-penicillamine is one of the disease-modifying anti-rheumatic drugs (dmards). drug-induced pemphigus is not frequently associated with d-penicillamine, and to date, the number of reported cases is about a hundred. most reports of d-penicillamine-induced pemphigus vulgaris are in patients with rheumatoid arthritis. it has rarely been reported in patients not taking d-penicillamine. we report a ...

introduction: adhesion formation after pelvic surgery is still a major cause of several morbidities such as infertility, pain, bowel obstruction and subsequent intra-operative complications. our aim was to investigate the effects of d-penicillamine in preventing adhesion formation in rat uterine horn. methods: this experimental trial was conducted on 30 rats. the rats were randomly assigned to ...

BACKGROUND Adhesions formation is a significant postsurgical complication. At present, there is no effective method for preventing adhesions formation 1, although barrier products such as Dextran (Dex) 2 and sodium hyaluronate (SH) 3 have proved the most clinically successful 456, This study is designed to investigate the preventive and therapeutic potential of a novel penicillamine-bound membr...

background: this study was performed to investigate the adverse effects of acute lead intoxication on hemogram, erythrocyte osmotic fragility and oxidant/antioxidant status and the probable ameliorating effect of silymarin in comparison to d-penicillamine. methods: forty-eight albino rats were divided in 8 groups and received the following treatments in a 10 day experiment in shahid chamran uni...

Background: This study was performed to investigate the adverse effects of acute lead intoxication on hemogram, erythrocyte osmotic fragility and oxidant/antioxidant status and the probable ameliorating effect of silymarin in comparison to d-penicillamine. Methods: Forty-eight albino rats were divided in 8 groups and received the following treatments in a 10 day experiment in Shahid Chamran ...

D-penicillamine is one of the disease-modifying anti-rheumatic drugs (DMARDs). Drug-induced pemphigus is not fre-quently associated with D-penicillamine, and to date, the number of reported cases is about a hundred. Most reports of D-penicillamine-induced pemphigus vulgaris are in patients with rheumatoid arthritis. It has rarely been reported in patients not taking D-penicillamine. We report a...

Between 1973 and 1979, 203 patients with classical or definite rheumatoid arthritis were treated with chloroquine phosphate, gold, or penicillamine. Of 132 receiving penicillamine, 76 received it as the sole treatment. Forty of 50 withdrawals from penicillamine were side effect-related, although 4 of these 50 subsequently resumed therapy. Nineteen showed no response to penicillamine. Eight-six ...

It was shown in a previous communication (Crawhall et al., 1963) that the abnormally high level of cystine excretion found in homozygotes for cystinuria could be reduced for short periods by the administration of D-penicillamine. This paper reports the results of administering the drug continuously to a group of cystinuric patients for periods of five months to one year. We have used the D-isom...

The activity of aspartate aminotransferase a vitamin B6 containing enzyme was measured in the laysed synaptosomes prepared from rat brain, during development. Administration of vitamin B6 increased the enzyme activity throughout development. The stimulating effect of this vitamin was prevented when the animals were previously treated with D-penicillamine. However, penicillamine alone had n...

the activity of aspartate aminotransferase a vitamin b6 containing enzyme was measured in the laysed synaptosomes prepared from rat brain, during development. administration of vitamin b6 increased the enzyme activity throughout development. the stimulating effect of this vitamin was prevented when the animals were previously treated with d-penicillamine. however, penicillamine alone had no eff...