The main aim of this study was determination of thermo- radio- and photostability of perindopril tert-butyloamine (PER) therefore the efficiency and safety of the therapy could be maintained. A chromatographic method (RP-HPLC) had been validated before use to determine PER loss. The evaluation of stability properties of PER in solid state under the influence of isothermal condition, relative hu...

The main aim of this study was determination of thermo- radio- and photostability ofperindopril tert-butyloamine (PER) therefore the efficiency and safety of the therapy could bemaintained.A chromatographic method (RP-HPLC) had been validated before use to determinePER loss. The evaluation of stability properties of PER in solid state under the influence ofisothermal condition, relative humidit...

The main aim of this study was determination of thermo- radio- and photostability ofperindopril tert-butyloamine (PER) therefore the efficiency and safety of the therapy could bemaintained.A chromatographic method (RP-HPLC) had been validated before use to determinePER loss. The evaluation of stability properties of PER in solid state under the influence ofisothermal condition, relative humidit...

S05590 is a fixed-dose combination of perindopril tert-butylamine 4 mg/indapamide 1.25 mg, and S06593 arginine 5 mg/amlodipine mg. The purpose this study was to determine whether pharmacokinetic interactions exist among the components S06593, compared with amlodipine as reference drugs, in healthy Chinese male volunteers after single oral administration under fasting conditions. A single-center...

A novel stability indicating gradient reverse-phased high-performance liquid chromatographic method has been developed for the quantification of impurities of perindopril tert-butylamine (PER) in pharmaceutical dosage form. Separation of the active substance and its known (Impurities B, C, D, E, F) and unknown impurities was achieved on a BDS Hypersil C18 column (250 mm × 4.6 mm, 5 µm), thermos...

We examined the effects of the angiotensin-converting enzyme inhibitor perindopril and the b-blocker propranolol on dilator responses of cerebral arterioles in chronic hypertension. Dilator responses to acute hypotension were examined in untreated Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) that were untreated or treated for 3 months with a low (0.3 mg · kg ...

BACKGROUND Angiotensin-converting enzyme inhibitors (ACEI) have a well-established role in the prevention of cardiovascular events in hypertension, left ventricular dysfunction, and heart failure. More recently, ACEI have been shown to prevent cardiovascular events in individuals with increased cardiovascular risk, where hypertension, left ventricular dysfunction, or heart failure was not the p...

CONTEXT Aortic stiffness is increased in Marfan syndrome contributing to aortic dilatation and rupture, the major cause of premature death in this population. Angiotensin-converting enzyme inhibitors have been shown to reduce arterial stiffness. OBJECTIVE To determine whether perindopril therapy reduces aortic stiffness and attenuates aortic dilatation in patients with Marfan syndrome. DESI...

Mục tiêu: Đánh giá kết quả kiểm soát nồng độ homocystein máu và huyết áp ở bệnh nhân tăng mới phát hiện bằng perindopril. Đối tượng phương pháp: Nghiên cứu mô tả cắt ngang trên 105 tại Bệnh viện Trường Đại học Y dược Cần Thơ từ năm 2017-2018. Kết quả: Nồng trung bình sau điều trị thấp hơn trước trị: 4,33 µmol/L, khoảng tin cậy 95%: 3,69 – 4,97, p< 0,001. Sau 6 tuần perindopril thì tỷ lệ giảm...

We examined the effects of the angiotensin-converting enzyme inhibitor perindopril and the beta-blocker propranolol on dilator responses of cerebral arterioles in chronic hypertension. Dilator responses to acute hypotension were examined in untreated Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) that were untreated or treated for 3 months with a low (0.3 mg. k...