periodontitis (pd) is known to be one of most prevalent worldwide chronic inflammatory diseases. there are several treatments including antibiotics for pd; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. the effects of trans-anethole on il-1 β and tnf-α level in a rat model of pd were investigated and comp...

Periodontitis (PD) is known to be one of most prevalent worldwide chronic inflammatory diseases. There are several treatments including antibiotics for PD; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. The effects of trans-anethole on IL-1 β and TNF-α level in a rat model of PD were investigated and comp...

The treatment of chronic periodontitis consists of conventional mechanical debridement and removal of plaque and calculus'. Topical NSAIDs could be used to complement the therapy as an adjunct to resolve the inflammatory process and clinical signs of the disease more rapidly. A randomized clinical trial was performed on 33 systemically healthy patients diagnosed with chronic periodontitis, aged...

BACKGROUND Ketoprofen is a non-steroidal anti-inflammatory drug which has been widely used for domestic animals. Orally administered racemic ketoprofen has been reported to be absorbed well in pigs, and bioavailability was almost complete. The objectives of this study were to analyze R- and S-ketoprofen concentrations in plasma after oral (PO) and intra muscular (IM) routes of administration, a...

Drug-induced photosensitivity reactions are significant adverse effects. Ketoprofen is one of the most common drugs that can cause skin rash in sun-exposed areas. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ketoprofen, are often used for a variety of symptoms, including pain and fever. An understanding of the presentation and clinical course of ketoprofen-induced photosensitivity is...

BACKGROUND The aim of this study was to determine the effect of initial therapy with some disease modifying antirheumatic drugs (DMARDs) (Methotrexate and Ketoprofen) on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA). OBJECTIVES OBJECTIVES To determine whether there is a change in clinical and laboratory indicators of renal function in course of the follow up o...

Ketoprofen is a non-steroidal anti-inflammatory compound (NSAID) which has low solubility in water. The aim of this study was to increase the dissolution rate ketoprofen by forming multicomponent ketoprofen-Proline with ratio 1:1, 1:2, and 2:1 using solid state grinding method. Samples were characterized Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transf...

Purpose: To study the immunosuppressant and immunopotentiating effects of ketoprofen on antibodyproducing cells. Methods: Mice were given ketoprofen at doses of 1 mg/kg/day and 5 mg/kg/day for seven days. Similarly polyinosinic–polycytidylic acid (Poly IC) and phosphate buffer saline (PBS) were used as positive and negative control, respectively, for seven days. After seven days, the mice were ...