Diosgenin is a steroidal saponin isolated from dioscorea opposita, which has been proven to have anti-cancer, anti-inflammatory, anti-thrombotic and immune system modulating effects in large number of pharmacological tests. also one the important raw materials for synthesis drugs, structural modification diosgenin obtain derivatives can not only improve solubility dissolution, but enhance their...

Having validated analysis methods for medicinal ingredients is attractive for pharmaceutical companies. When a new molecule is introduced to the market, there is not any pharmacopeial analysis method for that. After publishing official methods, correlation between validated in-house methods and the official one could stablish the value of the in-house method. Sitagliptin phosphate is a new anti...

A new spectral library-based approach that is capable of screening a diverse set of finished drug products using only an active pharmaceutical ingredient spectral library is described in this paper. This approach obviates the need for a comprehensive drug product library, thereby streamlining the use of spectral library-based tests for anti-counterfeiting efforts, specifically to target finishe...

The crystal structures of dimorphic benzylthiouracil, a drug against hyperthyroidism, have been redetermined and the atom coordinates two independent molecules form I obtained for first time. dimorphism convincingly demonstrates conformational versatility benzylthiouracil molecule. It has established through calorimetric studies that low-temperature II transforms endothermically (?II?IH = 5.6(1...