tetracycline may be used to treat several types of bacterial diseases in ruminants. in addition, tetracycline is added to food to promote the growth. there are few reports on the pharmacokinetics of tetracycline in sheep. therefore, the objective of this study was to examine the pharmacokinetic characteristics of the drug in sheep. ten apparently healthy mixed-breed sheep were administered 20 m...

fluconazole is commonly used both to prevent and to treat invasive neonatal candida albicans infection. this drug is a potent, selective, triazole inhibitor of the fungal enzymes involved in ergosterol synthesis. it is largely excreted unchanged in the urine. in infants with a birth weight <1,500 grams, fungal infection is approximately 3% to 4%. up to 30% of infants with invasive candidiasis d...

tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. to date, there is no information on the pharmacokinetics of tacrolimus in iranian liver transplant recipients. this study was designed to determine pharmacokinetic properties of orally administe...

six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. blood samples were collected before and at various time intervals after the administration of the drug. serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. non...

background methotrexate is a folic acid antagonist that has been in clinical use for five decades. its use in patients with brain tumors is primarily confined to primary central nervous system lymphoma (pcnsl), in which it is the cornerstone of chemotherapy. objectives a selective and sensitive high-performance liquid chromatography-electrospray ionization-mass spectrometry method was developed...

background: omeprazole is metabolized predominantly by cyp2c19, a polymorphically expressed enzymes that show marked interindividual and interethnic variation. these variations cause a substantial differences that have been reported in the pharmacokinetics of omeprazole. the aim of the present study was to evaluate the pharmacokinetic parameters of omeprazole in a random iranian population. met...

teicoplanin is a glycoside antibiotic which consists of five closely related glycopeptide antibiotics with similar antibacterial properties to vancomycin that were first isolated in 1976. teicoplanin is active against many gram-positive anaerobe microorganisms and is particularly potent against clostridium species. it is also active against most listeria, enterococci and staphylococci including...

conclusions both protocols provide excellent anesthesia, but patients receiving sufentnail had more stable anesthesia and less postoperative pain. objectives we planned to compare two clinical protocols for tiva with propofol, and either sufentanil or alfentanil in regards to postoperative pain, hemodynamic stability during the case and time for emergence from anesthesia. patinets and methods t...

background: a simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in human plasma. methods: the mobile phase composed of acetonitrile-water 60:40 (v/v) and 0.2% formic acid 20 µl of sample was chromatographically analyzed using a repacked zorbax-xdb-ods c18 column (2.1 mmx30...

background: azithromycin (azm) is used in periodontal infections. the present study compared gingival crevicular fluid concentration of azithromycin of two pharmaceutical companies through the hplc method. methods: two groups (n=15) of healthy volunteers participated in this study. the first group received an imported azithromycin (imazm) tablet (250 mg, po) and the second group received an azi...