Mycobacterium tuberculosis salicylate synthase (MbtI) catalyses the first committed step in the biosynthesis of mycobactin T, an iron-chelating siderophore essential for the virulence and survival of M. tuberculosis. Co-crystal structures of MbtI with members of a first generation inhibitor library revealed large inhibitor-induced rearrangements within the active site of the enzyme. This plasti...

Enantioenriched, highly functionalized cyclopropane derivatives were prepared by a simple and green approach using monosaccharide-based chiral crown ethers as phase transfer catalysts. The Michael-initiated ring closure (MIRC) reactions of diethyl bromomalonate with 2-cyano-3-phenylacrylate took place complete diastereoselectivity in the presence lariat derived from carbohydrates enantioselecti...