Paramutation generates heritable changes affecting regulation of specific alleles found at several Zea mays (maize) loci that encode transcriptional regulators of anthocyanin biosynthetic genes. Although the direction and extent of paramutation is influenced by poorly understood allelic interactions occurring in diploid sporophytes, two required to maintain repression loci (rmr1 and rmr2), as w...

background: downy mildew caused by plasmopara halstedii is one of the most devastating diseases of sunflower worldwide. so far several dominant resistance genes designated as pl have been identified and their molecular markers linked to these genes are available. however, no information on the resistance genes is available in iranian lines. objective: in this study, the presence of three map-ba...

A genetic screen identified two novel gene functions required to maintain mitotically and meiotically heritable gene silencing associated with paramutation of the maize purple plant 1 (pl1) locus. Paramutation at pl1 leads to heritable alterations of pl1 gene regulation; the Pl-Rhoades (Pl-Rh) allele, which typically confers strong pigmentation to juvenile and adult plant structures, changes to...

Background: Downy mildew caused by Plasmopara halstedii is one of the most devastating diseases of sunflower worldwide. So far several dominant resistance genes designated as Pl have been identified and their molecular markers linked to these genes are available. However, no information on the resistance genes is available in Iranian lines. Objective: In this study, the presence of three map-b...

Interactions between specific maize purple plant1 (pl1) alleles result in heritable changes of gene regulation that are manifested as differences in anthocyanin pigmentation. Transcriptionally repressed states of Pl1-Rhoades alleles (termed Pl') are remarkably stable and invariably facilitate heritable changes of highly expressed states (termed Pl-Rh) in Pl'/Pl-Rh plants. However, Pl' can rever...

Structural elements are key elements for understanding single-stranded nucleic acid folding. Although various RNA structural elements have been documented, structural elements of single-stranded DNA (ssDNA) have rarely been reported. Herein, we determined a crystal structure of PvLDH in complex with a DNA aptamer called pL1. This aptamer folds into a hairpin-bulge contact by adopting three nove...

Coronaviruses (CoVs), such as human coronavirus NL63 (HCoV-NL63), severe acute respiratory syndrome CoV (SARS-CoV), murine hepatitis virus (MHV), porcine epidemic diarrhea virus (PEDV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), encode papain-like (PL) proteases that inhibit Sendai virus- (SeV-) induced interferon (IFN-β) production. Recently, the crystal structure of transmis...

Paramutation is a bizarre but likely widespread phenomenon that violates Mendel’s Law of Segregation. In this process, one allele changes the activity state of its partner allele on the homologous chromosome, usually from an active state to a silent state. This new state is inherited by the next generation and beyond. What’s more, the newlymodified allele has the ability to change the activity ...

BACKGROUND Visceral pleural invasion (VPI) is generally considered a poor prognostic factor in non-small cell lung cancer (NSCLC). VPI is defined as penetration beyond the elastic layer of visceral pleura (PL1), including the visceral pleural surface without the involvement of adjacent structures (PL2) by cancer cells. The aim of this study was to evaluate the influence of the extent of VPI on ...