multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. many studies have shown that inflammation causing neuronal demyelination. ms is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. platelet activating fact...

platelet activating factor (paf) is a novel signaling phospholipids that in addition to platelet activation has many biological properties. the acrosome reaction, as an essential step in mammalian fertilization, can occur in response to several agents such as paf. therefore, the present study aimed to assess the effect of paf on the motility and acrosome reaction of ram spermatozoa. semen was c...

Dithranol is a potent agent in treating psoriasis but its adverse effects on intact skin have limited its usage. There are many proposed mediators for its adverse effects including prostaglandins, histamine, platelet activating factor and free radicals. In this study we examined the effect of different agents (diazepam, terfenadine, indomethacin and garlic extract) on dithranol-induced skin dam...

Platelet activating factor (PAF-ACETHER or PAF) and precursors of platelet activating factor were investigated in 26 patients with acute Crohn's disease and in 10 healthy controls. Platelet activating factor, lyso platelet activating factor, and alkyl acyl glycerophosphocholine, were determined in colonic mucosal biopsies in patients with acute Crohn's disease, during prednisolone therapy, and ...