introduction: ischemic preconditioning mediated by potassium channels is a physiological protective mechanism, . it is hypothesized that nicorandil, which is a potassium channel activator, could protect the heart via preconditioning. materials and methods:this clinical trial was conducted on 162 patients undergoing percutaneous coronary intervention (pci) in quem hospital, from jan2013 to jan 2...

introduction: a large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in alzheimer's disease (ad). it has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. the aim of this study was to investigate...

Introduction: A large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in Alzheimer's disease (AD). It has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. The aim of this study was to investigate the ...

Preconditioning with brief ischemia before a sustained period of ischemia reduces infarct size in the perfused heart. A cultured chick ventricular myocyte model was developed to investigate the role of adenosine receptor subtypes in cardiac preconditioning. Brief hypoxic exposure, termed preconditioning hypoxia, prior to prolonged hypoxia, protected myocytes against injury induced by the prolon...

Non-linear optimization problems suffer from local minima. When we use gradient based iterative solvers on these problems, we often find the final solution highly dependent on the initial guess. Here we introduce preconditioning and show how it helps resolve in our current problem—bidirectional deconvolution. The results in three data examples show that preconditioning helps us get a more spiky...

Background: Occupational noise-induced hearing loss (ONIHL) is a hearing disorder that affects workers all over the world. Preconditioning with several mild or less potent stressors will effectively prevent the development of noise-induced hearing loss. This study investigated the possible preventive effects of normobaric hyperoxia preconditioning on preventing the noise-induced hearing impairm...

Abstract Naïve T cells and regulatory cells, when purified, do not proliferate to the common cytokine receptor γ-chain family cytokines interleukin (IL)-2, IL-7 or IL-15, despite their expression of cognate receptors. Cell-to-cell contact with dendritic (DCs) enabled proliferation cell these cytokines, independent antigen recognition stimulation. This effect lasted after separation from DCs, en...

organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. the pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. in this review, we discuss basic mechanisms...

objective(s):gentamicin sulphate (gs) nephrotoxicity seems to be related to the generation of reactive oxygen species. there is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. materials and methods: forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily gs, groups 3,4 and 5 received oxygen 2 hr/day...