نتایج جستجو برای: Predictive Biomarker

تعداد نتایج: 196512  

Journal: :Annals of Oncology 2017

Journal: :Journal of the National Cancer Institute 2013
Mei-Yin C Polley Boris Freidlin Edward L Korn Barbara A Conley Jeffrey S Abrams Lisa M McShane

Predictive biomarkers to guide therapy for cancer patients are a cornerstone of precision medicine. Discussed herein are considerations regarding the design and interpretation of such predictive biomarker studies. These considerations are important for both planning and interpreting prospective studies and for using specimens collected from completed randomized clinical trials. Specific issues ...

Journal: :Nature Reviews Clinical Oncology 2019

Journal: :gastroenterology and hepatology from bed to bench 0
akram safaei afsaneh arefi oskouie seyed reza mohebbi mostafa rezaei-tavirani mohammad mahboubi maryam peyvandi

metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. in cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (nafld) and non-alcoholic steatotic hepatitis (nash) the  liver  does not function thoroughly due to long-term damage. unfortunately the early detection of cirrhosis, hcc, na...

2011
Kinga Malottki Mousumi Biswas Jon Deeks Richard Riley Charles Craddock Lucinda Billingham

Objectives Stratified medicine has been defined as using a biomarker to match a patient to a cohort that has exhibited a differential response to a treatment. This is important where the proportion of patients benefiting from treatment is low and possible adverse events can be serious. To maximise patient benefit, valid predictive biomarkers need to be used. Several trial designs have been prop...

2013
Jiayu Zhou Jimeng Sun Fei Wang Jianying Hu Shahram Ebadollahi Jieping Ye

In the longitudinal study measurements of various biomarkers are taken from the same set of patients repeatedly over long periods. The longitudinal data provides important temporal information about the development of diseases. When applying standard data mining techniques to perform biomarker analysis and build predictive models to study diseases, typically the important temporal relationship ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Douglas Yee

Type I insulin-like growth factor (IGF) receptor (IGF1R) inhibitors are new cancer therapies. Pitts and colleagues used in vitro data to "train" a predictive biomarker for an IGF1R tyrosine kinase inhibitor. Given the complexity of IGF signaling, additional layers of biomarker analysis will likely be needed to develop predictive factors.

Journal: :Computer methods and programs in biomedicine 2011
Jessica Lin Jacquelyn D. Parente J. Geoffrey Chase Geoffrey M. Shaw Amy J. Blakemore Aaron J. Le Compte Christopher G. Pretty Normy N. Razak Dominic S. Lee Christopher E. Hann Sheng-Hui Wang

Sepsis occurs frequently in the intensive care unit (ICU) and is a leading cause of admission, mortality, and cost. Treatment guidelines recommend early intervention, however positive blood culture results may take up to 48 h. Insulin sensitivity (S(I)) is known to decrease with worsening condition and could thus be used to aid diagnosis. Some glycemic control protocols are able to accurately i...

2018
Yingying Zhou Xinyi Wang Yuanyuan Zhang Tong Zhao Zhongyan Shan Weiping Teng

Citation: Zhou Y, Wang X, Zhang Y, Zhao T, Shan Z and Teng W (2018) Circulating MicroRNA Profile as a Potential Predictive Biomarker for Early Diagnosis of Spontaneous Abortion in Patients With Subclinical Hypothyroidism. Front. Endocrinol. 9:128. doi: 10.3389/fendo.2018.00128 circulating Microrna Profile as a Potential Predictive Biomarker for early Diagnosis of spontaneous abortion in Patient...

Introduction: Galectin-3 is known as a biomarker in patients with heart failure. This protein participates in different mechanisms involved in atherosclerosis including inflammation and plaque formation. This study was conducted to investigate whether this factor could be a predictive biomarker for the severity of atherosclerosis. Materials and Methods: The study group consisted of 80 patients ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید