نتایج جستجو برای: Predictive Biomarker
تعداد نتایج: 196512 فیلتر نتایج به سال:
Predictive biomarkers to guide therapy for cancer patients are a cornerstone of precision medicine. Discussed herein are considerations regarding the design and interpretation of such predictive biomarker studies. These considerations are important for both planning and interpreting prospective studies and for using specimens collected from completed randomized clinical trials. Specific issues ...
metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. in cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (nafld) and non-alcoholic steatotic hepatitis (nash) the liver does not function thoroughly due to long-term damage. unfortunately the early detection of cirrhosis, hcc, na...
Objectives Stratified medicine has been defined as using a biomarker to match a patient to a cohort that has exhibited a differential response to a treatment. This is important where the proportion of patients benefiting from treatment is low and possible adverse events can be serious. To maximise patient benefit, valid predictive biomarkers need to be used. Several trial designs have been prop...
In the longitudinal study measurements of various biomarkers are taken from the same set of patients repeatedly over long periods. The longitudinal data provides important temporal information about the development of diseases. When applying standard data mining techniques to perform biomarker analysis and build predictive models to study diseases, typically the important temporal relationship ...
Type I insulin-like growth factor (IGF) receptor (IGF1R) inhibitors are new cancer therapies. Pitts and colleagues used in vitro data to "train" a predictive biomarker for an IGF1R tyrosine kinase inhibitor. Given the complexity of IGF signaling, additional layers of biomarker analysis will likely be needed to develop predictive factors.
Sepsis occurs frequently in the intensive care unit (ICU) and is a leading cause of admission, mortality, and cost. Treatment guidelines recommend early intervention, however positive blood culture results may take up to 48 h. Insulin sensitivity (S(I)) is known to decrease with worsening condition and could thus be used to aid diagnosis. Some glycemic control protocols are able to accurately i...
Citation: Zhou Y, Wang X, Zhang Y, Zhao T, Shan Z and Teng W (2018) Circulating MicroRNA Profile as a Potential Predictive Biomarker for Early Diagnosis of Spontaneous Abortion in Patients With Subclinical Hypothyroidism. Front. Endocrinol. 9:128. doi: 10.3389/fendo.2018.00128 circulating Microrna Profile as a Potential Predictive Biomarker for early Diagnosis of spontaneous abortion in Patient...
Introduction: Galectin-3 is known as a biomarker in patients with heart failure. This protein participates in different mechanisms involved in atherosclerosis including inflammation and plaque formation. This study was conducted to investigate whether this factor could be a predictive biomarker for the severity of atherosclerosis. Materials and Methods: The study group consisted of 80 patients ...
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