Over a 5-year period, three cases of thyrotoxic pretibial myxoedema were encountered. The incidence of pretibial myxoedema in Chinese thyrotoxic patients in Singapore was 0-7yo (03y. in females and 1F6% in males). One of the three patients also had thyroid acropachy. The incidence of thyrotoxic pretibial myxoedema in Singapore is compared with that in the literature and the aetiology briefly re...

INTRALESIONAL HYALURONIDASE WITH TRIAMCINOLONE FOR RECALCITRANT PRETIBIAL MYXEDEMA Abstract Pretibial myxedema resulting in progressively worsening cutaneous induration and expanding nodules can lead to pain, discomfort and functional impairment. Treatment of resistant lesions presents a special challenge whereby topical therapies are insufficient, and systemic therapies are met with poor toler...

Pretibial myxedema (PTM) is usually a late manifestation of Graves' disease and is relatively rare. The elephantiasis nostras variant comprises less than one percent of patient with pretibial myxedema. We report two cases of elephantiasic PTM and review the literature regarding its treatment. Therapy of the elephantiasic variant of PTM remains suboptimal at present. ( J Intern Med Taiwan 2004; ...

Peripheral edema is observed as an adverse effect of the usage of antipsychotics in the literature. This case report describes a 36-year-old female patient with the diagnosis of paranoid schizophrenia who presented with pretibial edema following initiation of long-acting injectable paliperidone palmitate. Pretibial edema developed within the second week of treatment and completely disappeared a...

Background. Pretibial myxedema (PTM) is a rare dermopathy. The morphologic features and mechanism of its evolving process are not reported in large case series. Methods. 216 cases with PTM were retrospectively reviewed to analyze demographics, history, lesional morphology and its evolving process, histopathology and immunohistochemistry, serum TRAb levels, treatment, and outcome. Results. First...

Infiltrative dermopathy is an uncommon manifestation of Graves' disease. The most frequent location of infiltration is the lower extremities, especially the pretibial areas and on the dorsum of the foot. Rarely the hand, elbow, arm, and forearm are affected. We report a 66-year-old man with Graves' disease of nine years duration who presented with dermopathy and nonpitting edema of the toe with...