Objective(s): It is known that extremely low frequency-pulsed electromagnetic fields (ELF-PEMF) influence multiple cellular and molecular processes. Retinal pigment epithelial (RPE) cells have a significant part in the emergence and pathophysiology of several ocular disorders, such as neovascularization. This study assessed the impact of ELF-PEMF on the proangiogenic features of RPE cells. Mate...

In the present study, we investigated whether proangiogenic growth factors and endothelial progenitor cells (EPCs) induce favourable effects on cutaneous incisional wound healing in diabetic mice. The proangiogenic effects of human EPCs were initially analyzed using a HUVEC in vitro angiogenesis assay and an in vivo Matrigel assay in nude mice (n=12). For the diabetic wound model, 48 Balb/c mic...

Abstract Summary: Natural killer (NK) cells accumulate at the fetal–maternal interface and represent 70% of immune in decidua (dNK) first-trimester pregnancy; they are immune-tolerant toward semiallogenic fetus “nurturing” nonkilling NK cells. A subset patients with cancer have features common dNK, which include expressing CD56, CD9, CD49a, CXCR3, being poorly cytotoxic proangiogenic, mimicking...

Active self-encapsulation (ASE) is a recently developed post-loading method based on absorption of (positively charged) proteins in microporous PLGA microspheres loaded with negatively charged polysaccharides (trapping agents). The aim this study was to investigate ASE for simultaneous loading and controlled release multiple growth factors. For purpose, vascular endothelial factor (VEGF), fibro...

BACKGROUND Numerous proangiogenic growth factors have been shown to improve impaired wound healing. This study evaluated the effects of subcutaneous pretreatment with a combination of proangiogenic growth factors on wound closure, mechanical properties, vessel density, and morphology. METHODS Thirty-six Balb/c mice with streptozotocin-induced diabetes were divided into 3 groups. A mixture of ...

Mast cells (MCs) are common components of inflammatory infiltrates and a source of proangiogenic factors. Inflammation is often accompanied by vascular changes. However, little is known about modulation of MC-derived proangiogenic factors during inflammation. In this study, we evaluated the effects of the proinflammatory mediator prostaglandin E2 (PGE2) on MC expression and release of proangiog...