نتایج جستجو برای: Quantitative determination

تعداد نتایج: 552539  

Journal: :iranian journal of chemistry and chemical engineering (ijcce) 2014
seyyed hamid ahmadi hassan tavakoli majid amirzadeh mohammad reza sangi

a new fourier transform-infra red (ft-ir) spectrometric method was developed for assaying hydrochlorothiazide (hct) and enalapril maleate (enm) in binary solid pharmaceutical formulations. multivariate partial least squares (pls) method was used for calibration of derivative spectral data. acetonitrile was used as solvent due to its spectral transparency and adequate solubility of analytes in i...

Journal: :Genetics 1999
J M Henshall M E Goddard

Experiments to map QTL usually measure several traits, and not uncommonly genotype only those animals that are extreme for some trait(s). Analysis of selectively genotyped, multiple-trait data presents special problems, and most simple methods lead to biased estimates of the QTL effects. The use of logistic regression to estimate QTL effects is described, where the genotype is treated as the de...

Journal: :Genetical research 2004
Nusrat Rabbee David Speca Nicola J Armstrong Terence P Speed

Selective genotyping concerns the genotyping of a portion of individuals chosen on the basis of their phenotypic values. Often individuals are selected for genotyping from the high and low extremes of the phenotypic distribution. This procedure yields savings in cost and time by decreasing the total number of individuals genotyped. Previous work by Darvasi et al. (1993) has shown that the power...

Journal: :Genetics 2006
Matthew J Brauer Cheryl M Christianson Dave A Pai Maitreya J Dunham

We demonstrate a new method, microarray-assisted bulk segregant analysis, for mapping traits in yeast by genotyping pooled segregants. We apply a probabilistic model to the progeny of a single cross and as little as two microarray hybridizations to reliably map an auxotrophic marker, a Mendelian trait, and a major-effect quantitative trait locus.

Journal: :Genetics 2007
Ani Manichaikul Abraham A Palmer Saunak Sen Karl W Broman

In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.

Journal: :Human molecular genetics 2016
Buhm Han Dat Duong Jae Hoon Sul Paul I W de Bakker Eleazar Eskin Soumya Raychaudhuri

Meta-analysis strategies have become critical to augment power of genome-wide association studies (GWAS). To reduce genotyping or sequencing cost, many studies today utilize shared controls, and these individuals can inadvertently overlap among multiple studies. If these overlapping individuals are not taken into account in meta-analysis, they can induce spurious associations. In this article, ...

Journal: :Genetics 2007
Meng Chen Christina Kendziorski

In 2001, Sen and Churchill reported a general Bayesian framework for quantitative trait loci (QTL) mapping in inbred line crosses. The framework is a powerful one, as many QTL mapping methods can be represented as special cases and many important considerations are accommodated. These considerations include accounting for covariates, nonstandard crosses, missing genotypes, genotyping errors, mu...

Journal: :Acta Chemica Scandinavica 1960

Journal: :Scientific American 1879

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