BACKGROUND Worldwide, streptokinase remains the most used thrombolytic agent for the treatment of myocardial infarction. Recombinant streptokinase, from E. coli, is increasingly used in developing countries as a biosimilar of native streptokinase; however, potency assignments relative to the WHO International Standard (IS) are highly variable with potentially dangerous consequences. A proportio...

p90 ribosomal S6 kinase (RSK) is an important downstream effector of mitogen-activated protein kinase, but its biological functions are not well understood. We have now identified the first small-molecule, RSK-specific inhibitor, which we isolated from the tropical plant Forsteronia refracta. We have named this novel inhibitor SL0101. SL0101 shows remarkable specificity for RSK. The major deter...

RSK is normally defined in terms of a somewhat complicated procedure called row-insertion. This definition unfortunately masks the remarkable symmetry property that if A RSK 7−−−→ (P,Q) then At RSK 7−−−→ (Q,P ). Here we present an alternate description of RSK via local transformations that makes the symmetry obvious. Our approach is thus similar in spirit to the growth diagrams of Fomin [6]. In...

We present a version of the RSK correspondence based on Pitman transform and geometric considerations. This unifies ordinary RSK, dual continuous RSK. show that this is both bijection an isometry, two crucial properties for taking limits last passage percolation models. use bijective property to give non-computational proof maps Bernoulli walks nonintersecting walks.

The homodyned K-distribution appears naturally in the context of random walks and provides a useful model for the distribution of the received intensity in a wide range of non-Gaussian scattering configurations, including medical ultrasonics. An estimation method for the homodyned K-distribution based on the first moment of the intensity and two log-moments (XU method), namely the X and U-stati...

The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related serine/threonine kinases that regulate diverse cellular processes, including cell growth, proliferation, survival and motility. This family includes four vertebrate isoforms (RSK1, RSK2, RSK3 and RSK4), and single family member orthologues are also present in Drosophila and Caenorhabditis elegans. The RSK isoforms a...

In this paper, we propose a generalized version of the Rashmi-Shah-Kumar Minimum-Storage-Regenerating(RSKMSR) codes based on the product-matrix framework. For any (n, k, d) such that d ≥ 2k − 2 and d ≤ n − 1, we can directly construct an (n, k, d) MSR code without constructing a larger MSR code and shortening of the larger MSR code. As a result, the size of a finite field over which the propose...

Prostate cancer is one of the leading causes death among men worldwide; Some data suggest that ribosomal S6 p90 kinase (RSK 1-4), which belongs to group highly conserved Ser/Thr kinases, has been related an increase in prostate levels. For this reason, aim study was evaluate theoretical interaction some quinolone derivatives (compounds 1-19) with RSK-4 using 6rv2 protein and RSK-14 inhibitor (L...

The cell cycle in oocytes generally arrests at a particular meiotic stage to await fertilization. This arrest occurs at metaphase of meiosis II (meta-II) in frog and mouse, and at G1 phase after completion of meiosis II in starfish. Despite this difference in the arrest phase, both arrests depend on the same Mos-MAPK (mitogen-activated protein kinase) pathway, indicating that the difference rel...

Studies using pharmacological and genetic approaches have shown that increased activity/expression of the Na+/H+ exchanger isoform 1 (NHE1) play a critical role in the pathogenesis of cardiac hypertrophy. Despite the importance of NHE1 in cardiac hypertrophy, severe cerebrovascular side effects were associated with the use of NHE1 inhibitors when administered to patients with myocardial infarct...