The goal in external beam radiotherapy for cancer is to maximize tumor-damage while limiting toxic effects of radiation on nearby healthy anatomies. This is achieved through spatial localization and temporal dispersion of radiation dose. Once a radiation intensity profile that achieves the maximum possible spatial localization is designed at the beginning of a multi-week treatment-course, the t...

A dynamical system model for tumor-immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. The dependency of the results on system parameter values is studied. Conclusions for treatment optimization and patient classification are drawn from the statistic treatment of the...

introduction: secondary radiation such as photoelectrons, auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external x-ray beam after being loaded with elements capable of activating the tumor, e.g.; i and gd. materials and methods:  in this investigation, the mcnpx code was used for simulation and calculation of dose enhancement facto...

A triple-variable Integral Equation for Tumor Control Cumulative Probability (TCCP) is developed with the addition of important radiotherapy Treatment-Time parameter. Based on a previous double TCCP depending Biological Model parameters (α , β ), NEffective model implemented in (TCP) equation. Results comprise three essential Radiation Therapy precise determination TCCP. Solution shows method t...

In this paper, interactive multiobjective optimization for radiotherapy treatment planning is studied. The aim of radiotherapy is to destroy a tumor without causing damage to healthy tissue and treatment planning is used to achieve an optimal dose distribution. In intensity modulated radiotherapy (IMRT), the intensity of the incoming radiation flux can be modulated using some aperture such as a...

Introduction: Radiotherapy (RT) plays a major role in the management of breast cancer. Cardiac Toxicity is an important late complication of radiotherapy for left sided Breast cancer. Cardiac morbidity can be minimized through careful treatment planning. Aim: To study the variation of dose to the heart by change in the depth of normalization point during Radiotherapy planning. Settings and desi...