Background & Aims: Today, diabetic nephropathy is considered to be one of the most common causes of end stage renal disease. Uncontrolled hyperglycemia, and consequently, production of advanced glycation end products activate pathways which play key roles in diabetic nephropathy. Among these pathways, high expression of receptor for advanced glycation end products (RAGE) and transforming growth...

the recognition of apoptotic cells by phagocytes is a complex, yet highly orchestrated event. Many receptors have been identified that recognize phosphatidylserine (pS; Fig 1)—which is exposed on early apoptotic cells—leading to downstream signalling and apoptotic cell engulfment. in this issue of EMBo reports, the receptor for advanced glycation endproducts (ragE) is described as a new pS rece...

in this study, we examined the antioxidant activities of methanolic extract of three endemic species of salvia from iran (s. lachnocalyx, s. reuterana and s. sahendica) employing various established in vitro systems including ferric reducing antioxidant power, trolox equivalent antioxidant capacity assay and scavenging of 1,1-diphenyl-2-picrylhydrazyl radical. the results revealed that s. reute...

Patients with diabetes mellitus are at increased risk of restenosis after coronary artery stenting. Chronic hyperglycemia is associated with advanced glycation end products excessive production. There are data that in-stent restenosis in patients with diabetes mellitus may be related to plasma level of advanced glycation end products. One of the reasons for this is that protein glycation by alt...