Anovulation is a common cause of female subfertility. Treatment of anovulation is aimed at induction of ovulation. In women with clomiphene-citrate resistant WHO group II anovulation, one of the treatment options is ovulation induction with exogenous follicle-stimulating hormone (FSH or follitropin). FSH is derived from urine or is produced as recombinant FSH. Two forms of recombinant FSH are a...

background: polycystic ovary syndrome (pcos) is a common cause of ovulatory disorders and infertility with high lh to fsh ratio. in order to prevent further increase of lh and follicle atresia, different regimens for ovulation induction have been recommended using fsh alone.   objective: this study was performed in pcos patients to compare art outcomes in cycles induced by fsh alone, using eith...

Follicle-stimulating hormone (FSH) is the pituitary hormone responsible for testicular tubal development and ovarian follicular recruitment and maturation. Both recombinant and purified urinary FSH are currently used for ovulation induction in women undergoing assisted reproduction. In this report, we describe Chinese hamster ovary (CHO-K1) cell expression of a novel long-acting human FSH singl...

Background: Bovine follicle stimulating hormone (bFSH) belongs to the family of glycoprotein hormones that are released from the pituitary gland or the placenta. This hormone is a heterodimer consisting of common α- and specific β-subunit. Bovine FSH is used for reproductive technology such as superovulation in farm animals and polycystic ovary syndrome treatment. Also this hormone is produced ...

objective: since there is still controversy regarding the best first-line choice for ovulation induction (oi) other than clomiphene citrate (cc) in infertile women diagnosed with polycystic ovary syndrome (pcos), the aim of the present study was to compare recombinant human fsh with cc as the first course of oi in these women. materials and methods: in this pilot randomized controlled trial, 10...

OBJECTIVE A small amount of LH is necessary for 17beta-estradiol production in the ovarian follicle. Human menopausal gonadotropin (hMG) contains equal amounts of FSH and LH activity, whereas recombinant FSH is a gonadotropin preparation without LH. The aim of the present randomized study was to investigate whether ovarian stimulation treatment with recombinant FSH or hMG resulted in different ...

OBJECTIVE To evaluate the effect of low levels of endogenous luteinizing hormone (LH) and low-dose human chorionic gonadotropin (hCG) supplementation on in vitro fertilization (IVF) cycle outcomes in a gonadotropin-releasing hormone (GnRH) antagonist protocol. DESIGN Retrospective study. SETTING Military medical center. PATIENT(S) General in vitro fertilization/embryo transfer (IVF-ET) po...

The gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are important hormones in vertebrate reproduction. The isolation of gonadotropins from the pituitary gland is sub-optimal, as the cross-contamination of one hormone with another is common and often results in the variation in the measured activity of LH and FSH. The production of recombinant hormones is, therefo...