Anti-CD3 therapy of type 1 diabetes results in a temporary halt of its pathogenesis but does not constitute a permanent cure. One problem is the reinfiltration of islets of Langerhans with regenerated, autoaggressive lymphocytes. We aimed at blocking such a reentry by neutralizing the key chemokine CXCL10. Combination therapy of diabetic RIP-LCMV and NOD mice with anti-CD3 and anti-CXCL10 antib...

Cancer progression involves the seeding of malignant cells in circulation and the colonization of distant organs. However, circulating neoplastic cells can also reinfiltrate the tumor of origin. This process, called "tumor-self seeding," can select more aggressive cells that may contribute to cancer progression. Here, using mouse mammary adenocarcinoma models, we observed that both tumor self-s...

Cancer progression involves the seeding ofmalignant cells in circulation and the colonization of distant organs. However, circulating neoplastic cells can also reinfiltrate the tumor of origin. This process, called "tumor-self seeding," can selectmore aggressive cells thatmay contribute to cancer progression. Here, usingmousemammary adenocarcinoma models, we observed that both tumor self-seedin...

Abstract Integrated hydrological modelling (IHM) can reliably characterize surface-water/groundwater interactions in complex systems such as hard-rock (HRS), located water-limited environments (WLE). Such HRS-WLE conditions are represented by Sardon catchment (~80 km 2 ) Spain, where the MODFLOW 6 environment was tested, applying following improvements compared to previous works that catchment:...

This paper considers distributed hydrological models in hydrology as an expression of a pragmatic realism. Some of the problems of distributed modelling are discussed including the problem of nonlinearity, the problem of scale, the problem of equifinality, the problem of uniqueness and the problem of uncertainty. A structure for the application of distributed modelling is suggested based on an ...